Results 71 to 80 of about 1,520,842 (344)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Clinical application of single nucleotide polymorphism array in prenatal diagnosis: Experience with 8753 samples.

PLoS ONE
BackgroundSingle nucleotide polymorphism (SNP) array has been applied to prenatal diagnosis. This study aimed to assess the clinical significance of SNP array in diagnosing fetal chromosomal anomalies based on our experience.MethodsA total of 8753 ...
Li Wen, Yanzhen Zhang, Wen Zhang, Aifen Mao, Xiangjuan Li   +4 more
doaj   +1 more source

Genome-wide patterns of population structure and association mapping of nut-related traits in Persian walnut populations from Iran using the Axiom J. regia 700K SNP array

Scientific Reports, 2019
Persian plateau (including Iran) is considered as one of the primary centers of origin of walnut. Sampling walnut trees originating from this arena and exploiting the capabilities of next-generation sequencing (NGS) can provide new insights into the ...
M. Arab, A. Marrano, R. Abdollahi-Arpanahi, C. Leslie, H. Askari, D. Neale, K. Vahdati   +6 more
semanticscholar   +1 more source

Development of SNP‐genotyping arrays in two shellfish species [PDF]

Molecular Ecology Resources, 2014
AbstractUse of SNPs has been favoured due to their abundance in plant and animal genomes, accompanied by the falling cost and rising throughput capacity for detection and genotyping. Here, we present in vitro (obtained from targeted sequencing) and in silico discovery of SNPs, and the design of medium‐throughput genotyping arrays for two oyster species,
Marion Ballenghien, Philippe Gayral, Philippe Gayral, Emilie Flahauw, Christophe Klopp, Cécile Donnadieu, Lucie Genestout, L. Barbotte, Serge Heurtebise, Estelle Harrang, Pierrick Haffray, Sylvie Lapegue, R. Mahla   +12 more
openaire   +3 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Development and validation of a Pacific Abalone (Haliotis discus hannai) custom 60K SNP array

Aquaculture Reports
The Pacific abalone (Haliotis discus hannai) is a commercially important abalone species native to South Korea, which is immensely popular as a seafood delicacy.
Jeong Woen Shin, Sangwon Yoon, Seung Hwan Lee, Jung-Youn Park, Jong-Won Park, Hyun-Chul Kim, Woo-Jin Kim, Young-Ok Kim, Dongwon Seo, Eun Soo Noh   +9 more
doaj   +1 more source

Application of Single Nucleotide Polymorphism Microarray in Prenatal Diagnosis of Fetuses with Central Nervous System Abnormalities

International Journal of General Medicine, 2021
Xiaorui Xie, Xiaoqing Wu, Linjuan Su, Meiying Cai, Ying Li, Hailong Huang, Liangpu Xu Medical Genetic Diagnosis and Therapy Center, Fujian Key Laboratory for Prenatal Diagnosis and Birth Defect, Fujian Provincial Maternity and Children’s Hospital ...
Xie X, Wu X, Su L, Cai M, Li Y, Huang H, Xu L   +6 more
doaj  

QTL mapping of adult plant resistance to stripe rust in the Fundulea 900 × Thatcher RIL population

Czech Journal of Genetics and Plant Breeding, 2021
Wheat stripe rust, caused by Puccinia striiformis Westend. f.sp. tritici Eriks (Pst), is one of the most important diseases of bread wheat worldwide. Breeding resistant wheat cultivars is the most economical, effective and environmentally friendly way ...
Xiaocui Yan, Huimin Zheng, Peipei Zhang, Gebrewahid Takele Weldu, Zaifeng Li, Daqun Liu   +5 more
doaj   +1 more source

High Resolution Mapping of QTLs for Heat Tolerance in Rice Using a 5K SNP Array

Rice, 2017
BackgroundHeat stress is one of the major abiotic threats to rice production, next to drought and salinity stress. Incidence of heat stress at reproductive phase of the crop results in abnormal pollination leading to floret sterility, low seed set and ...
Shanmugavadivel Ps, A. Sv, C. Prakash, Ramkumar Mk, R. Tiwari, T. Mohapatra, N. Singh   +6 more
semanticscholar   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source