Results 171 to 180 of about 220,745 (323)

Screening of biobank SNP-array genotyping data to detect Lynch syndrome predisposing MLH1 copy number variants [PDF]

K Ala-Kulju, Olli Carpén, Maarit Lappalainen, Minja Pehrsson   +3 more
openalex   +1 more source

Pathway‐Informed Machine Learning Identifies Genetic Predictors of High‐Dose Methotrexate‐Induced Mucositis in Pediatric Acute Lymphoblastic Leukemia

Clinical Pharmacology &Therapeutics, EarlyView.
High‐dose methotrexate for pediatric cancer treatment is frequently associated with mucositis, which can lead to delayed or discontinued treatment and impact survival. While individual genetic variants have been implicated, the cumulative impact of genetic variation within relevant biological pathways remains unexplored.
Xiao Yu Cindy Zhang, Erika N. Scott, Hedy Maagdenberg, Alice Man, Kathy H. Li, S. Rod Rassekh, Bruce C. Carleton, Colin J. D. Ross, Wyeth W. Wasserman, Catrina M. Loucks   +9 more
wiley   +1 more source

Development of a 135K SNP genotyping array for Actinidia arguta and its applications for genetic mapping and QTL analysis in kiwifruit. [PDF]

Plant Biotechnol J, 2023
Wang R, Xing S, Bourke PM, Qi X, Lin M, Esselink D, Arens P, Voorrips RE, Visser RGF, Sun L, Zhong Y, Gu H, Li Y, Li S, Maliepaard C, Fang J.   +15 more
europepmc   +1 more source

SNP Design from 454 Sequencing of Podosphaera plantaginis Transcriptome Reveals a Genetically Diverse Pathogen Metapopulation with High Levels of Mixed-Genotype Infection

, 2012
Charlotte Tollenaere, Hanna Susi, Jussi Nokso-Koivisto, Patrik Koskinen, Ayco J. M. Tack, Petri Auvinen, Lars Paulín, Mikko J. Frilander, Rainer Lehtonen, Anna‐Liisa Laine   +9 more
openalex   +2 more sources

Prognostic Implication of CYP2C19 Genotype According to Clinical Risk Stratification After Drug‐Eluting Stent Implantation

Clinical Pharmacology &Therapeutics, EarlyView.
From the nationwide multicenter consortium, 8,163 patients undergoing drug‐eluting stent implantation were classified according to the presence of the CYP2C19 loss‐of‐function (LoF) allele: rapid or normal metabolizers (RMs/NMs) vs. intermediate or poor metabolizers (IMs/PMs), and clinical risk was stratified using the CHADS‐P2A2RC and TRS 2°P scores ...
Hyun Woong Park, Jae‐Hwan Lee, Jin‐Ok Jeong, Diana A. Gorog, Udaya S. Tantry, Byeong‐Keuk Kim, Hyung Joon Joo, Kiyuk Chang, Jin‐Yong Hwang, Young Bin Song, Sung Gyun Ahn, Jung‐Won Suh, Woong Gil Choi, Jung Rae Cho, Jeehoon Kang, Sang Yeub Lee, Hyo‐Soo Kim, Moo Hyun Kim, Do‐Sun Lim, Eun‐Seok Shin, Paul A. Gurbel, Young‐Hoon Jeong, on behalf of the PTRG‐DES Consortium Investigators   +22 more
wiley   +1 more source

SNP Genotyping Characterizes the Genome Composition of the New Baisary Fat-Tailed Sheep Breed. [PDF]

Animals (Basel), 2022
Zhumadillayev N, Dossybayev K, Khamzina A, Kapasuly T, Khamzina Z, Tlevlesov N.   +5 more
europepmc   +1 more source

Application of RE-SNPs genotyping in phylogenic studies of Bacillus anthracis in Iran [PDF]

, 2015
Mohammad Hadi Sekhavati, Taghi Naserpour Farivar, Majid Esmaelizad, Keyvan Tadayon   +3 more
openalex  

The first high-density sequence characterized SNP-based linkage map of olive (Olea europaea L. subsp. europaea) developed using genotyping by sequencing

, 2016
Annalisa Marchese, Francesco Paolo Marra, Tiziano Caruso, Khethani Give Mhelembe, Francesca Costa, Silvia Fretto, Daniel James Sargent   +6 more
openalex   +1 more source

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, EarlyView.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Rapid and accurate SNP genotyping of clonal bacterial pathogens with BioHansel. [PDF]

Microb Genom, 2021
Labbé G, Kruczkiewicz P, Robertson J, Mabon P, Schonfeld J, Kein D, Rankin MA, Gopez M, Hole D, Son D, Knox N, Laing CR, Bessonov K, Taboada EN, Yoshida C, Ziebell K, Nichani A, Johnson RP, Van Domselaar G, Nash JHE.   +19 more
europepmc   +1 more source