Results 11 to 20 of about 97,365 (285)

“Spot-On” SNP Genotyping: Figure 1. [PDF]

Genome Research, 2000
As we enter the post-genomic era, where complete reference genome sequences are a given, analyzing the variation among individual genomes is an area of intense investigation. One of the most common forms of genomic variation is single nucleotide polymorphisms, or SNPs. The “science of SNPs” has become a heavy industry, as evidenced by the proliferation
Michael C. Ellis
openalex   +5 more sources

High-Throughput SNP Genotyping by SBE/SBH

, 2005
Despite much progress over the past decade, current Single Nucleotide Polymorphism (SNP) genotyping technologies still offer an insufficient degree of multiplexing when required to handle user-selected sets of SNPs.
Ion Măndoiu, Claudia Prăjescu
openalex   +6 more sources

High‐Throughput SNP Genotyping [PDF]

ChemInform, 2002
AbstractWhole genome approaches using single nucleotide polymorphism (SNP) markers have the potential to transform complex disease genetics and expedite pharmacogenetics research. This has led to a requirement for high‐throughput SNP genotyping platforms. Development of a successful high‐throughput genotyping platform depends on coupling reliable assay
Suzanne Jenkins, Neil James Gibson
openaire   +4 more sources

Unifying candidate gene and GWAS Approaches in Asthma. [PDF]

, 2010
The first genome wide association study (GWAS) for childhood asthma identified a novel major susceptibility locus on chromosome 17q21 harboring the ORMDL3 gene, but the role of previous asthma candidate genes was not specifically analyzed in this GWAS ...
Berg, Andrea von, Bufe, Albrecht, Depner, Martin, Frischer, Thomas, Genuneit, Jon, Gut, Ivo G., Heinzmann, Andrea, Illig, Thomas, Kabesch, Michael, Klopp, Norman, Kumar, Ashish, Lathrop, Mark, Laub, Otto, Liang, Liming, Michel, Sven, Mutius, Erika von, Rietschel, Ernst, Ruether, Andreas, Schedel, Michaela, Schreiber, Stefan, Simma, Burkhard, Vogelberg, Christian   +21 more
core   +16 more sources

GBS-SNP-CROP: a reference-optional pipeline for SNP discovery and plant germplasm characterization using variable length, paired-end genotyping-by-sequencing data [PDF]

, 2016
Background: With its simple library preparation and robust approach to genome reduction, genotyping-by-sequencing (GBS) is a flexible and cost-effective strategy for SNP discovery and genotyping, provided an appropriate reference genome is available. For
Bartaula, Radhika, Hale, Iago L., Tavares De Oliveira Melo, Arthur   +2 more
core   +2 more sources

Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays [PDF]

, 2007
High-throughput SNP genotyping platforms use automated genotype calling algorithms to assign genotypes. While these algorithms work efficiently for individual platforms, they are not compatible with other platforms, and have individual biases that result
Edward M. Smith, Hardenbol, Hardenbol, Hua, Huentelman, Jack Littrell, Kissebah, Lamy, Liu, McPeek, Michael Olivier, Olivier, Rabbee, Smith, Sonnenberg, Xiao   +15 more
core   +2 more sources

Forensic SNP genotyping using nanopore MinION sequencing [PDF]

, 2017
One of the latest developments in next generation sequencing is the Oxford Nanopore Technologies' (ONT) MinION nanopore sequencer. We studied the applicability of this system to perform forensic genotyping of the forensic female DNA standard 9947 A using
Cornelis, Senne, Deforce, Dieter, Deleye, Lieselot, Gansemans, Yannick, Van Nieuwerburgh, Filip   +4 more
core   +2 more sources

A nanoliter fluidic platform for large-scale single nucleotide polymorphism genotyping

BioTechniques, 2009
Discovery, evaluation, and understanding the biological relevance of single nucleotide polymorphisms (SNPs) and their associated phenotypes is relevant to many applications, including human disease diagnostics, pathogen detection, and identification of ...
Douglas G. Roberts, Tom B. Morrison, Shau Neen Liu-Cordero, Jamie Cho, Javier Garcia, Tanya S. Kanigan, Kevin Munnelly, Colin J.H. Brenan   +7 more
doaj   +1 more source

Effect of Combining Multiple CNV Defining Algorithms on the Reliability of CNV Calls from SNP Genotyping Data [PDF]

Genomics & Informatics, 2012
In addition to single-nucleotide polymorphisms (SNP), copy number variation (CNV) is a major component of human genetic diversity. Among many whole-genome analysis platforms, SNP arrays have been commonly used for genomewide CNV discovery.
Soon-Young Kim, Ji-Hong Kim, Yeun-Jun Chung   +2 more
doaj   +1 more source

Comparison of PrASE and Pyrosequencing for SNP Genotyping [PDF]

BMC Genomics, 2006
Abstract Background There is an imperative need for SNP genotyping technologies that are cost-effective per sample with retained high accuracy, throughput and flexibility. We have developed a microarray-based technique and compared it to Pyrosequencing.
Marie-Louise Persson, Max Käller, Max Käller, Kristina Holmberg, Jacob Odeberg, Jacob Odeberg, Emilie Hultin, Joakim Lundeberg, Afshin Ahmadian   +8 more
openaire   +3 more sources