Results 21 to 30 of about 337,686 (261)
Single Nucleotide Polymorphisms (SNPs) are variations that occur at single nucleotides in the genome and are present at an appreciable level in a population.
Roger D. Lawrie, Steven E. Massey
doaj +1 more source
Genotyping pooled DNA using 100K SNP microarrays: a step towards genomewide association scans [PDF]
The identification of quantitative trait loci (QTLs) of small effect size that underlie complex traits poses a particular challenge for geneticists due to the large sample sizes and large numbers of genetic markers required for genomewide association ...
Plomin, R. +14 more
core +1 more source
Background Current World Health Organization guidelines for conducting anti-malarial drug efficacy clinical trials recommend genotyping Plasmodium falciparum genes msp1 and msp2 to distinguish recrudescence from reinfection.
Joseph Fulakeza +10 more
doaj +1 more source
Special features of RAD Sequencing data:implications for genotyping [PDF]
Restriction site-associated DNA Sequencing (RAD-Seq) is an economical and efficient method for SNP discovery and genotyping. As with other sequencing-by-synthesis methods, RAD-Seq produces stochastic count data and requires sensitive analysis to develop ...
Fuentes-Utrilla, Pablo +12 more
core +1 more source
A nanoliter fluidic platform for large-scale single nucleotide polymorphism genotyping
Discovery, evaluation, and understanding the biological relevance of single nucleotide polymorphisms (SNPs) and their associated phenotypes is relevant to many applications, including human disease diagnostics, pathogen detection, and identification of ...
Douglas G. Roberts +7 more
doaj +1 more source
Genotyping by genome reducing and sequencing for outbred animals. [PDF]
Next-generation sequencing (NGS) approaches are widely used in genome-wide genetic marker discovery and genotyping. However, current NGS approaches are not easy to apply to general outbred populations (human and some major farm animals) for SNP ...
Qiang Chen +16 more
doaj +1 more source
Two new rapid SNP-typing methods for classifying Mycobacterium tuberculosis complex into the main phylogenetic lineages [PDF]
There is increasing evidence that strain variation in Mycobacterium tuberculosis complex (MTBC) might influence the outcome of tuberculosis infection and disease.
Coscollà Mireia +54 more
core +3 more sources
Pooled DNA genotyping on Affymetrix SNP genotyping arrays
Background Genotyping technology has advanced such that genome-wide association studies of complex diseases based upon dense marker maps are now technically feasible. However, the cost of such projects remains high.
Owen Michael J +5 more
doaj +1 more source
The development and characterization of a 60K SNP chip for chicken [PDF]
Background In livestock species like the chicken, high throughput single nucleotide polymorphism (SNP) genotyping assays are increasingly being used for whole genome association studies and as a tool in breeding (referred to as genomic selection).
Vereijken, Addie +41 more
core +2 more sources
Temperature Switch PCR (TSP): Robust assay design for reliable amplification and genotyping of SNPs
Background Many research and diagnostic applications rely upon the assay of individual single nucleotide polymorphisms (SNPs). Thus, methods to improve the speed and efficiency for single-marker SNP genotyping are highly desirable.
Mather Diane E +2 more
doaj +1 more source

