Results 231 to 240 of about 215,087 (323)

TAMGeS: a Three-Array Method for Genotyping of SNPs by a dual-colour approach [PDF]

open access: gold, 2007
A Cozza   +5 more
openalex   +1 more source

Geographic containment and virulence‐resistance trade‐offs drive the evolution of hypervirulent Klebsiella pneumoniae

open access: yesiMeta, EarlyView.
The global emergence of hypervirulent, carbapenem‐resistant Klebsiella pneumoniae (hvCRKP) poses a paradox: why do such dangerous clones remain geographically confined? By analyzing over 2500 CC23 genomes across 90 years, we uncover a core evolutionary constraint—virulence and resistance rarely coexist without trade‐offs. Potent carbapenemases (blaKPC,
Yuchen Wu   +15 more
wiley   +1 more source

High-Throughput SNP Genotyping by Single-Tube PCR with T m -Shift Primers

open access: gold, 2005
Jun Wang   +7 more
openalex   +1 more source

Inferring missing genotypes in large SNP panels using fast nearest-neighbor searches over sliding windows [PDF]

open access: hybrid, 2007
Adam P. Roberts   +5 more
openalex   +1 more source

From multi‐omics to precision medicine in intracranial aneurysm: Biomarker discovery and multimodal integration

open access: yesInterdisciplinary Medicine, EarlyView.
This review explores intracranial aneurysm biomarker discovery through multi‐omics. It reveals key genes, proteins, and metabolites, and shows how machine‐learning‐based multi‐modal integration may aid diagnosis and treatment. Abstract Despite extensive research, currently, no biomarkers are available for clinical use in intracranial aneurysm (IA ...
Jiaxin Zhang   +4 more
wiley   +1 more source

Recent advances in isothermal amplification techniques coupled with clustered regularly interspaced short palindromic repeat/Cas systems

open access: yesInterdisciplinary Medicine, EarlyView.
Abstract Isothermal amplification (IA) techniques have emerged as promising alternatives to polymerase chain reaction (PCR), enabling rapid and efficient nucleic acid amplification at constant temperatures. Meanwhile, clustered regularly interspaced short palindromic repeat (CRISPR)/Cas‐based technology has revolutionized molecular diagnostics by ...
Miao Liu   +7 more
wiley   +1 more source

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