Results 241 to 250 of about 223,459 (323)

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

open access: yesMolecular Carcinogenesis, EarlyView.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler   +7 more
wiley   +1 more source

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

open access: yesMed Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li   +8 more
wiley   +1 more source

Genotype distributions of the tag-SNPs and their associations with the NPI Total Score.

open access: green
Francesco Bruno (3430520)   +25 more
openalex   +1 more source

LRRK2 as a Potential Disease‐Modifying Target in Sporadic Parkinson's Disease

open access: yesMovement Disorders, EarlyView.
Abstract A growing understanding of the role that leucine‐rich repeat kinase 2 (LRRK2) plays in Parkinson's disease (PD) supports continued focus on this enzyme as a therapeutic target for PD. Accumulating evidence suggests that there are phenotypic, neuropathologic, and biological similarities between sporadic PD (sPD) and familial forms in which ...
Anthony E. Lang   +12 more
wiley   +1 more source

Veronica paczoskiana is no more than a pine forest ecotype of V. spicata that evolved independently in forest‐steppes of Ukraine and the Altai region

open access: yesNordic Journal of Botany, EarlyView.
The Eurasian steppe area has been a dynamic vegetation biome during the Pleistocene with its repeated cycles of forest advances and retreats. Such a scenario allows the evolution of ecotypes at the ecotone with the potential for parallel evolution in different parts of the distribution area.
Dirk C. Albach   +4 more
wiley   +1 more source

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