Results 51 to 60 of about 201,829 (351)

Reference-free SNP calling: improved accuracy by preventing incorrect calls from repetitive genomic regions

Biology Direct, 2012
Background Single nucleotide polymorphisms (SNPs) are the most abundant type of genetic variation in eukaryotic genomes and have recently become the marker of choice in a wide variety of ecological and evolutionary studies.
Dou Jinzhuang, Zhao Xiqiang, Fu Xiaoteng, Jiao Wenqian, Wang Nannan, Zhang Lingling, Hu Xiaoli, Wang Shi, Bao Zhenmin   +8 more
doaj   +1 more source

Inference of kinship coefficients from Korean SNP genotyping data [PDF]

BMB Reports, 2013
The determination of relatedness between individuals in afamily is crucial in analysis of common complex diseases. Wepresent a method to infer close inter-familial relationshipsbased on SNP genotyping data and provide the relationshipcoefficient of ...
Seong-Jin Park, Jin Ok Yang, Sang Cheol Kim, Jekeun Kwon, Sanghyuk Lee, Byungwook Lee   +5 more
doaj   +1 more source

Simultaneous SNP identification in association studies with missing data [PDF]

Annals of Applied Statistics 2012, Vol. 6, No. 2, 432-456, 2012
Association testing aims to discover the underlying relationship between genotypes (usually Single Nucleotide Polymorphisms, or SNPs) and phenotypes (attributes, or traits). The typically large data sets used in association testing often contain missing values.
arxiv   +1 more source

Genotyping of SNPs in a Polyploid Genome by Pyrosequencing™ [PDF]

BioTechniques, 2002
Single-nucleotide polymorphisms (SNPs) are the most frequent DNA sequence variations, and they have become increasingly popular markers for association studies. Allelic discrimination of the mostly binary SNPs has been reported for diploid species, mainly the human, but not for polyploid genomes such as the agriculturally important crops.
Christiane Gebhardt, Andreas Premstaller, Andreas M. Rickert, Peter J. Oefner   +3 more
openaire   +4 more sources

Conflicting Results in SNP Genotype Assessment

BioTechniques, 2007
Single nucleotide polymorphisms (SNPs) are highly abundant in the genome and especially useful in the search for disease susceptibility genes via population-based association or linkage studies. Therefore, there is a strong need for high throughput and reliable methodologies to assess the SNP genotypes. Despite an unambiguous result of an SNP analysis,
Hansen, Lise Lotte, Madsen, Bo Eskerod, Pedersen, Kristina, Wiuf, Carsten   +3 more
openaire   +5 more sources

Methods for Scarless, Selection-Free Generation of Human Cells and Allele-Specific Functional Analysis of Disease-Associated SNPs and Variants of Uncertain Significance. [PDF]

, 2017
With the continued emergence of risk loci from Genome-Wide Association studies and variants of uncertain significance identified from patient sequencing, better methods are required to translate these human genetic findings into improvements in public ...
Carvajal-Carmona, Luis G, Coggins, Nicole B, O'Geen, Henriette, Segal, David J, Stultz, Jacob   +4 more
core   +4 more sources

Examination of runs of homozygosity in relation to height in an endogamous Namibian population

American Journal of Biological Anthropology, Volume 180, Issue 1, Page 207-215, January 2023., 2023
Abstract Objectives Height is a complex, highly heritable polygenic trait subject to both genetic composition and environmental influences. Recent studies suggest that a large proportion of height heritability is determined by the cumulative effect of many low allele frequency variants across the genome. Previous research has also identified an inverse
Natalie Swinford, Brenna Gallagher, Jacob Sheehama, Meng Lin, Sean Prall, Brooke Scelza, Brenna M. Henn   +6 more
wiley   +1 more source

Comparison of TaqMan, KASP and rhAmp SNP genotyping platforms in hexaploid wheat.

PLoS ONE, 2019
Advances in high-throughput genotyping enable the generation of genome-scale data much more easily and at lower cost than ever before. However, small-scale and cost-effective high-throughput single-nucleotide polymorphism (SNP) genotyping technologies ...
Habtamu Ayalew, Pak Wah Tsang, Chenggen Chu, Junzhou Wang, Shuyu Liu, Caifu Chen, Xue-Feng Ma   +6 more
doaj   +1 more source

High-throughput genotyping of single nucleotide polymorphisms with rolling circle amplification

BMC Genomics, 2001
Background Single nucleotide polymorphisms (SNPs) are the foundation of powerful complex trait and pharmacogenomic analyses. The availability of large SNP databases, however, has emphasized a need for inexpensive SNP genotyping methods of commensurate ...
Sun Zhenyu, Zong Qiuling, Grimwade Brian, Kumar Gyanendra, Bandaru Rajanikanta, Alsmadi Osama, Dean Frank B, Driscoll Mark D, Hosono Seiyu, Faruqi A Fawad, Du Yuefen, Kingsmore Stephen, Knott Tim, Lasken Roger S   +13 more
doaj   +1 more source

Novel Design of Imputation-Enabled SNP Arrays for Breeding and Research Applications Supporting Multi-Species Hybridization

Frontiers in Plant Science, 2021
Array-based single nucleotide polymorphism (SNP) genotyping platforms have low genotype error and missing data rates compared to genotyping-by-sequencing technologies.
Gabriel Keeble-Gagnère, Raj Pasam, Kerrie L. Forrest, Debbie Wong, Hannah Robinson, Jayfred Godoy, Allan Rattey, David Moody, Daniel Mullan, Tresslyn Walmsley, Hans D. Daetwyler, Hans D. Daetwyler, Josquin Tibbits, Matthew J. Hayden, Matthew J. Hayden   +14 more
doaj   +1 more source