Results 21 to 30 of about 499,359 (306)

SNP-SNP interactions in breast cancer susceptibility [PDF]

BMC Cancer, 2006
AbstractBackgroundBreast cancer predisposition genes identified to date (e.g., BRCA1 and BRCA2) are responsible for less than 5% of all breast cancer cases. Many studies have shown that the cancer risks associated with individual commonly occurring single nucleotide polymorphisms (SNPs) are incremental.
Onay, Venüs Ü, Briollais, Laurent, Knight, Julia A, Shi, Ellen, Wang, Yuanyuan, Wells, Sean, Li, Hong, Rajendram, Isaac, Andrulis, Irene L, Ozcelik, Hilmi   +9 more
openaire   +4 more sources

Relationship of FTO gene variations with NAFLD risk in Chinese men

Open Life Sciences, 2020
Fat mass and obesity-associated (FTO) gene is an obesity susceptibility gene and its relationship with the nonalcoholic fatty liver disease (NAFLD) remains unclear.
Chen Xuefen, Gao Yong, Yang Xiaobo, Zhang Haiying, Mo Zengnan, Tan Aihua   +5 more
doaj   +1 more source

A Genome-Wide Association Study To Understand the Effect of Fusarium verticillioides Infection on Seedlings of a Maize Diversity Panel

G3: Genes, Genomes, Genetics, 2020
Fusarium verticillioides, which causes ear, kernel and stem rots, has been reported as the most prevalent species on maize worldwide. Kernel infection by F. verticillioides results in reduced seed yield and quality as well as fumonisin contamination, and
Lorenzo Stagnati, Vahid Rahjoo, Luis F. Samayoa, James B. Holland, Virginia M. G. Borrelli, Matteo Busconi, Alessandra Lanubile, Adriano Marocco   +7 more
doaj   +1 more source

Association between GLS Gene Polymorphisms and the Susceptibility to Lung Cancer in the Chinese Han Population

Frontiers in Bioscience-Landmark, 2023
Background: Lung cancer is one of the most serious malignant tumors endangering human health and life. This study focused on evaluating the association between single nucleotide polymorphisms (SNPs) of the glutaminase (GLS) and lung cancer susceptibility
Yuhe Wang, Mingyue Chen, Faling Yi, Jinpeng Xu, Changchun Liu, Ziyi Zhang, Ping Wang, Tianbo Jin, Mingwei Chen   +8 more
doaj   +1 more source

A second generation human haplotype map of over 3.1 million SNPs

Nature, 2007
We describe the Phase II HapMap, which characterizes over 3.1 million human single nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically diverse populations and includes 25–35% of common SNP variation in the populations ...
K. Frazer, D. Ballinger, D. Cox, D. Hinds, L. Stuve, R. Gibbs, J. Belmont, A. Boudreau, P. Hardenbol, S. Leal, S. Pasternak, D. Wheeler, T. Willis, F. Yu, Huanming Yang, Changqing Zeng, Yang Gao, Haoran Hu, Weitao Hu, Chaohua Li, Wei Lin, Siqi Liu, Hao Pan, Xiaoli Tang, Jian Wang, Wei Wang, Jun Yu, Bo Zhang, Qingrun Zhang, Hongbin Zhao, Hui-Ping Zhao, Jun Zhou, S. Gabriel, Rachel Barry, B. Blumenstiel, Amy L. Camargo, M. DeFelice, M. Faggart, Marie-Anne Goyette, Supriya Gupta, Jamie M Moore, Huy L. Nguyen, R. Onofrio, Melissa Parkin, J. Roy, E. Stahl, E. Winchester, L. Ziaugra, D. Altshuler, Yan Shen, Zhijian Yao, Wei Huang, X. Chu, Yungang He, Li Jin, Yangfan Liu, Yayun Shen, Weiwei Sun, Haifeng Wang, Yi Wang, Ying Wang, Xiao-yan Xiong, Liang Xu, M. Waye, S. Tsui, H. Xue, J. Wong, L. Galver, Jian-Bing Fan, K. Gunderson, S. Murray, A. Oliphant, M. Chee, A. Montpetit, F. Chagnon, V. Ferretti, M. Leboeuf, J. Olivier, M. Phillips, Stéphanie Roumy, C. Sallée, A. Verner, T. Hudson, P. Kwok, Dongmei Cai, D. Koboldt, Raymond D. Miller, Ludmila Pawlikowska, P. Taillon-Miller, M. Xiao, L. Tsui, W. Mak, You-Qiang Song, P. Tam, Yusuke Nakamura, T. Kawaguchi, T. Kitamoto, Takashi Morizono, A. Nagashima, Y. Ohnishi, A. Sekine, Toshihiro Tanaka, T. Tsunoda, P. Deloukas, C. Bird, Marcos Delgado, E. Dermitzakis, R. Gwilliam, S. Hunt, J. Morrison, Don Powell, Barbara E. Stranger, P. Whittaker, D. Bentley, M. Daly, P. D. de Bakker, J. Barrett, Y. Chretien, J. Maller, S. Mccarroll, N. Patterson, I. Pe’er, A. Price, S. Purcell, D. Richter, Pardis C Sabeti, R. Saxena, S. Schaffner, P. Sham, P. Varilly, Lincoln D. Stein, Lalitha Krishnan, A. Smith, M. Tello-Ruiz, Gudmundur A. Thorisson, A. Chakravarti, Peter E. Chen, D. Cutler, C. Kashuk, Shin Lin, G. Abecasis, W. Guan, Yun Li, Heather M. Munro, Zhaohui S. Qin, Daryl J. Thomas, G. McVean, A. Auton, L. Bottolo, Niall Cardin, S. Eyheramendy, C. Freeman, J. Marchini, S. Myers, C. Spencer, M. Stephens, P. Donnelly, L. Cardon, G. Clarke, David M. Evans, A. Morris, B. Weir, J. Mullikin, S. Sherry, M. Feolo, Andrew D. Skol, Houcan Zhang, I. Matsuda, Y. Fukushima, D. Macer, Eiko Suda, C. Rotimi, C. Adebamowo, I. Ajayi, Toyin Aniagwu, P. Marshall, Chibuzor Nkwodimmah, C. Royal, M. Leppert, M. Dixon, A. Peiffer, Renzong Qiu, A. Kent, Kazuto Kato, N. Niikawa, I. Adewole, B. Knoppers, Morris W. Foster, E. Clayton, Jessica Watkin, D. Muzny, L. Nazareth, E. Sodergren, G. Weinstock, I. Yakub, B. Birren, R. Wilson, L. Fulton, J. Rogers, J. Burton, N. Carter, C. Clee, M. Griffiths, Matthew C. Jones, K. McLay, R. Plumb, M. Ross, S. Sims, D. Willey, Zhu Chen, Hua Han, L. Kang, M. Godbout, J. Wallenburg, P. L'Archevêque, G. Bellemare, Koji Saeki, Hongguang Wang, Daochang An, Hongbo Fu, Qing Li, Zhen Wang, Ren-hao Wang, Arthur L. Holden, L. Brooks, J. Mcewen, M. Guyer, V. Wang, Jane L. Peterson, Michael Shi, J. Spiegel, L. M. Sung, Lynn F. Zacharia, F. Collins, Karen L Kennedy, R. Jamieson, J. Stewart   +236 more
semanticscholar   +1 more source

DNA methylation and single nucleotide variants in the brain-derived neurotrophic factor (BDNF) and oxytocin receptor (OXTR) genes are associated with anxiety/depression in older women

Frontiers in Genetics, 2015
Background: Environmental effects and personal experiences could be expressed in individuals through epigenetic non-structural changes such as DNA methylation. This methylation could up- regulate or down-regulate corresponding gene expressions and modify
Yvon eChagnon, Olivier ePotvin, Carol eHudon, Michel ePreville   +3 more
doaj   +1 more source

GENETIC VARIATION IN HOST IMMUNE RESPONSE TO MAJOR INFECTIOUS DISEASES IN BOVINES AND ITS APPLICATION IN ANIMAL BREEDING : A REVIEW [PDF]

Exploratory Animal and Medical Research, 2023
Livestock infectious diseases pose a significant threat to animal health and welfare on a worldwide scale, and efficient management of these diseases is essential for maintaining agronomic health, securing national and international food supply, and ...
Chhaya Rani, Anuj Chauhan, Indrasen Chauhan, Sakshi Vaishnav, Argana Ajay, Tapendra Saini , Snehasmita Panda , G. K Gaur , Bharat Bhushan   +8 more
doaj   +1 more source

SNP-sites: rapid efficient extraction of SNPs from multi-FASTA alignments

bioRxiv, 2016
Rapidly decreasing genome sequencing costs have led to a proportionate increase in the number of samples used in prokaryotic population studies. Extracting single nucleotide polymorphisms (SNPs) from a large whole genome alignment is now a routine task ...
A. Page, Ben Taylor, Aidan J. Delaney, Jorge Soares, T. Seemann, Jacqueline A. Keane, S. Harris   +6 more
semanticscholar   +1 more source

SNP interaction pattern identifier (SIPI): an intensive search for SNP–SNP interaction patterns [PDF]

Bioinformatics, 2016
Abstract Motivation Testing SNP–SNP interactions is considered as a key for overcoming bottlenecks of genetic association studies. However, related statistical methods for testing SNP–SNP interactions are underdeveloped.
Hui-Yi Lin, Dung-Tsa Chen, Po-Yu Huang, Yung-Hsin Liu, Augusto Ochoa, Jovanny Zabaleta, Donald Mercante, Zhide Fang, Thomas A. Sellers, Julio M. Pow-Sang, Chia-Ho Cheng, Rosalind A. Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G. Giles, Fredrik Wiklund, Henrik Gronberg, Christopher A. Haiman, Johanna Schleutker, Børge G. Nordestgaard, Ruth C. Travis, Freddie Hamdy, Nora Pashayan, Kay-Tee Khaw, Janet L. Stanford, William J. Blot, Stephen N. Thibodeau, Christiane Maier, Adam S. Kibel, Cezary Cybulski, Lisa A. Cannon-Albright, Hermann Brenner, Radka Kaneva, Jyotsna Batra, Manuel R. Teixeira, Hardev Pandha, Yong-Jie Lu, PRACTICAL Consortium, Jong Y. Park   +41 more
openaire   +6 more sources

ErbB polymorphisms: Insights and implications for response to targeted cancer therapeutics

Frontiers in Genetics, 2015
Advances in high-throughput genomic-scanning have expanded the repertory of genetic variations in DNA sequences encoding ErbB tyrosine kinase receptors in humans, including single nucleotide polymorphisms (SNPs), polymorphic repetitive elements ...
Moulay A Alaoui-Jamali, Gregoire Bernard Rene Morand, Sabrina Daniela Silva   +2 more
doaj   +1 more source