SNPsyn: detection and exploration of SNP–SNP interactions [PDF]
Nucleic Acids Research, 2011 SNPsyn (http://snpsyn.biolab.si) is an interactive software tool for the discovery of synergistic pairs of single nucleotide polymorphisms (SNPs) from large genome-wide case-control association studies (GWAS) data on complex diseases. Synergy among SNPs is estimated using an information-theoretic approach called interaction analysis.
Curk, Tomaz, Rot, Gregor, Zupan, Blaz
openaire +3 more sources
Ciencia Veterinaria, 2022 El complejo mayor de Histocompatibilidad (MHC del inglés: Major histocompatibility complex) en pollos (Gallus gallus) se encuentra localizado en un micro cromosoma, el 16 del genoma aviar. Así como ocurre en otras especies tiene una fuerte asociación con
Gabriela Marisa Iglesias
doaj +1 more source
Detecting epistasis via Markov bases [PDF]
, 2010 Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specific phenotype.
Malaspinas, Anna-Sapfo, Uhler, Caroline
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Accurate Genomic Prediction Of Human Height [PDF]
, 2017 We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning).
Avery, Steven G. +5 more
core +1 more source
Two single nucleotide polymorphisms in the caprine GnIH gene are associated with litter size
Czech Journal of Animal Science, 2017 Gonadotropin-inhibitory hormone (GnIH) can decrease luteinizing hormone and/or follicle-stimulating hormone levels in rat, mouse, sheep, and cattle by the direct suppression of gonadotropin-releasing hormone (GnRH).
Xiaopeng An +6 more
doaj +1 more source
Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. [PDF]
, 2012 Aims/hypothesisWhile genome-wide association studies (GWASs) have been successful in identifying novel variants associated with various diseases, it has been much more difficult to determine the biological mechanisms underlying these associations ...
Butte, AJ +6 more
core +2 more sources
Association of a synonymous mutation of the PGAM2 gene and growth traits in rabbits
Czech Journal of Animal Science, 2015 Phosphoglycerate mutase (PGAM2) catalyzes the conversion of 3-phosphoglycerate into 2-phosphoglycerate and releases energy during glycolysis in muscle tissues.
Z.-L. Wu +3 more
doaj +1 more source
High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast. [PDF]
, 2017 In yeast, DNA breaks are usually repaired by homologous recombination (HR). An early step for HR pathways is formation of a heteroduplex, in which a single-strand from the broken DNA molecule pairs with a strand derived from an intact DNA molecule.
Dominska, Margaret +3 more
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Association of bovine PPARGC1A and OPN genes with milk production and composition in Holstein cattle
Czech Journal of Animal Science, 2015 Several studies have reported quantitative trait loci on chromosome 6 affecting milk production and composition traits in dairy cattle. Osteopontin (OPN) and peroxisome proliferator activated receptor-γ coactivator-1α (PPARGC1A) genes have been located ...
M. Pasandideh +3 more
doaj +1 more source
How much of the variation in the mutation rate along the human genome can be explained? [PDF]
, 2014 It has been claimed recently that it may be possible to predict the rate of de novo mutation of each site in the human genome with a high degree of accuracy [Michaelson et al. (2012), Cell 151: 143121442]. We show that this claim is unwarranted.
Eyre-Walker, Adam +1 more
core +1 more source