Results 131 to 140 of about 15,972 (195)

The snRNA-seq data analysis of hippocampal interneurons resolves 15 distinct lineages

Erythropoietin (EPO) aids in rectifying hippocampal transcriptional networks and synaptic structures of pyramidal lineages, thereby mitigating mood and cognition-associated disorders. An imminent conundrum is how EPO restores synapses by involving interneurons.
openaire   +2 more sources

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen, Weishi Liu, Min Guo, Tongyao You, Yingzhe Wang, Tiansiyu Wen, Suzhen Liang, Xiaodi Xie, Yanfeng Jiang, Qiang Dong, Jin‐Tai Yu, Mei Cui   +11 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

snRNA-seq identifies Fmo2⁺ fibroblasts as drivers of hyperglycemic memory-induced cardiac injury. [PDF]

NPJ Metab Health Dis
Xu S, Ju C, Zhu M, Cai Y, Xu F, Liu Y, Liu Y.   +6 more
europepmc   +1 more source

Highly heterozygous Citrus changshan‐huyou Y. B. Chang originated from ancient hybridization between mandarin and pummelo and displayed distinct tissue‐specific allelic imbalance

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract The genus Citrus is characterized by a reticulate evolutionary history with frequent hybridization, making it an intriguing subject for genome evolution investigation. Citrus changshan‐huyou Y. B. Chang (Huyou) is a unique landrace first discovered in Zhejiang Province, China, with premium fruit quality.
Zhanghui Zeng, Yingjie Luo, Haifei Hu, Lan Lan, Baojin Guo, Ping Zhou, Cong Tan, Xiaoping Huang, Tuo Qi, Zhehao Chen, Zhiming Yu, Lilin Wang, Taihe Xiang, Chengdao Li, Yong Jia   +14 more
wiley   +1 more source

Partial domain adaptation enables cross domain cell type annotation between scRNA-seq and snRNA-seq. [PDF]

PLoS Comput Biol
Chen X, Zou Q, Cai Q, Chen X, Li W, Wang Y.   +5 more
europepmc   +1 more source

Multi‐Omics Integration Reveals Incomplete Reactivation of Developmental Cell‐Cycle Programs in Adult Human Infarcted Hearts

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Cross‐context integration of single‐nucleus, spatial, bulk transcriptomic, and chromatin accessibility data from human fetal and adult infarcted hearts reveals that infarct‐zone cardiomyocytes re‐enter the cell cycle but show insufficient reactivation of late mitotic and cytokinesis execution programs, suggesting that incomplete cytokinesis ...
Jieran Lyu, Yuki Kuramoto, Jun Li, Jong‐Kook Lee, Kyoko Hidaka, Yasushi Sakata   +5 more
wiley   +1 more source

Phosphate starvation induces root cell‐type‐specific transcriptional responses and alternative splicing

New Phytologist, Volume 250, Issue 5, Page 3212-3229, June 2026.
Summary Phosphate (Pi) is an essential nutrient for plant growth, and understanding how Arabidopsis thaliana root cells respond to Pi deficiency is crucial to decipher whole plant responses. We perform high‐resolution transcriptomic profiling across five distinct root cell types, identifying differentially expressed genes (DEGs) and differential ...
Mary‐Paz González‐García, Mónica Lanza, Victoria Baca‐González, Estefano Bustillo‐Avendaño, Laura Serrano‐Ron, Sara González‐Bodi, Jose M. García‐Mina, Ángel M. Zamarreño, María Garnica, Miguel A. Moreno‐Risueno, Elena Caro, Juan C. del Pozo   +11 more
wiley   +1 more source

An snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging. [PDF]

Sci Rep
Tennant N, Pavuluri A, Singh G, Cortez K, O'Connor-Giles K, Larschan E, Singh R.   +6 more
europepmc   +1 more source

Multi‐Omics Insights Into Anthraquinone Biosynthesis in Rheum tanguticum

Plant Biotechnology Journal, Volume 24, Issue 6, Page 3953-3968, June 2026.
ABSTRACT Rheum tanguticum is renowned for its medicinal properties, including purgative, anti‐inflammatory and hepatoprotective effects, primarily attributed to anthraquinones (AQs). However, the molecular mechanisms of AQs biosynthesis have largely been hindered by insufficient genomic resources and functional genomics investigations.
Shuo Zhao, Yuan Zong, Tao Wang, Jianan Li, Zengrong Ye, Famei Zhang, Guoying Zhou   +6 more
wiley   +1 more source