Results 91 to 100 of about 13,335 (199)

The architecture of resilience: a genome assembly of Myrothamnus flabellifolia sheds light on desiccation tolerance and sex determination

New Phytologist, Volume 249, Issue 2, Page 1063-1084, January 2026.
Summary Myrothamnus flabellifolia is a dioecious resurrection plant endemic to southern Africa that has become an important model for understanding desiccation tolerance. Despite its ecological and medicinal significance, genomic and transcriptomic resources for the species are limited.
Rose A. Marks, John T. Lovell, Sarah B. Carey, Llewelyn Van Der Pas, Nyaradzai M. Chimukuche, Tomáš Brůna, Christopher Plott, Jenell Webber, Anna Lipzen, Juying Yan, Diane Bauer, Joanne Bentley, Jayson Talag, Chloee M. McLaughlin, Kerrie Barry, Jane Grimwood, Jerry W. Jenkins, Jeremy Schmutz, Alex Harkess, Robert VanBuren, James Leebens‐Mack, Jill M. Farrant   +21 more
wiley   +1 more source

Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA [PDF]

The EMBO Journal, 2004
Communication between U1 and U2 snRNPs is critical during pre-spliceosome assembly; yet, direct connections have not been observed. To investigate this assembly step, we focused on Prp5, an RNA-dependent ATPase of the DExD/H family. We identified homologs of Saccharomyces cerevisiae Prp5 in humans (hPrp5) and Schizosaccharomyces pombe (SpPrp5), and ...
Yong-Zhen, Xu, Catherine M, Newnham, Sei, Kameoka, Tao, Huang, Maria M, Konarska, Charles C, Query   +5 more
openaire   +2 more sources

Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing

eLife, 2016
Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear.
Somsakul Pop Wongpalee, Ajay Vashisht, Shalini Sharma, Darryl Chui, James A Wohlschlegel, Douglas L Black   +5 more
doaj   +1 more source

Circadian rhythms and post-transcriptional regulation in higher plants [PDF]

, 2015
The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés, Yanovsky, Marcelo Javier   +1 more
core   +3 more sources

Autoantibodies in COVID‐19 convalescent plasma donors

Vox Sanguinis, Volume 121, Issue 1, Page 54-63, January 2026.
Abstract Background and Objectives Although COVID‐19 convalescent plasma (CCP) has been successfully used to treat several viral infections, its effectiveness in neutralizing severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and its broader immunological safety remain debated.
Katerina Jazbec Gradišar, Klemen Žiberna, Polonca Mali, Ivica Marić, Primož Rožman, Elvira Maličev   +5 more
wiley   +1 more source

The U1 snRNP Base Pairs with the 5′ Splice Site within a Penta-snRNP Complex [PDF]

Molecular and Cellular Biology, 2003
Recognition of the 5' splice site is an important step in mRNA splicing. To examine whether U1 approaches the 5' splice site as a solitary snRNP or as part of a multi-snRNP complex, we used a simplified in vitro system in which a short RNA containing the 5' splice site sequence served as a substrate in a binding reaction.
Hadar, Malca, Noam, Shomron, Gil, Ast
openaire   +2 more sources

A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

eLife, 2015
Prp3 is an essential U4/U6 di-snRNP-associated protein whose functions and molecular mechanisms in pre-mRNA splicing are presently poorly understood. We show by structural and biochemical analyses that Prp3 contains a bipartite U4/U6 di-snRNA-binding ...
Sunbin Liu, Sina Mozaffari-Jovin, Jan Wollenhaupt, Karine F Santos, Matthias Theuser, Stanislaw Dunin-Horkawicz, Patrizia Fabrizio, Janusz M Bujnicki, Reinhard Lührmann, Markus C Wahl   +9 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, Volume 19, Issue 12, Page 3784-3805, December 2025.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Functional inhibition of core spliceosomal machinery activates intronic premature cleavage and polyadenylation of pre-mRNAs

Cell Reports
Summary: The catalytic role of U6 snRNP in pre-mRNA splicing has been well established. In this study, we utilize an antisense morpholino oligonucleotide (AMO) specifically targeting catalytic sites of U6 snRNA to achieve functional knockdown of U6 snRNP
Qiumin Feng, Zejin Lin, Danhui Zhao, Mengzhao Li, Sheng Yang, Andy Peng Xiang, Congting Ye, Chengguo Yao   +7 more
doaj   +1 more source

Alternative Spliceosome Assembly Pathways Revealed by Single-Molecule Fluorescence Microscopy

Cell Reports, 2013
Removal of introns from nascent transcripts (pre-mRNAs) by the spliceosome is an essential step in eukaryotic gene expression. Previous studies have suggested that the earliest steps in spliceosome assembly in yeast are highly ordered and the stable ...
Inna Shcherbakova, Aaron A. Hoskins, Larry J. Friedman, Victor Serebrov, Ivan R. Corrêa, Jr., Ming-Qun Xu, Jeff Gelles, Melissa J. Moore   +7 more
doaj   +1 more source