The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3′-end processing of animal histone mRNAs [PDF]
, 2017 Metazoan replication-dependent histone pre-mRNAs undergo a unique 3′-cleavage reaction which does not result in mRNA polyadenylation. Although the cleavage site is defined by histone-specific factors (hairpin binding protein, a 100-kDa zinc-finger ...
Azzouz, Teldja N. +6 more
core
Antisense oligonucleotide binding to U5 snRNP induces a conformational change that exposes the conserved loop of U5 snRNA [PDF]
, 1997 Gil Ast
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Impaired minor tri-snRNP assembly generates differential splicing defects of U12-type introns in lymphoblasts derived from a type I SMA patient [PDF]
, 2010 Nawal Boulisfane +5 more
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Function of AFF1 in P-TEFb network [PDF]
, 2016 在真核细胞中，编码蛋白的基因转录是由RNA聚合酶II（RNAPolII）通过一系列复杂有序的调控机制完成的。不断深入的研究表明过去不受重视的转录延伸步骤也存在高度有序，极为精细的调控机制，这主要得益于正性转录延伸因子b（positive-transcriptionelongationfactorb，P-TEFb）的发现及对其功能的研究。P-TEFb复合体是由激酶CDK9（Cyclindependentkinase）及其调节亚基CycT1（CyclinT1）组成的异二聚体 ...
陆华松
core
Nuclear exchange of the U1 and U2 snRNP-specific proteins. [PDF]
, 1990 Robert J. Feeney, Gary W. Zieve
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A unique mechanism of snRNP core assembly
Nature CommunicationsThe assembly of most spliceosomal snRNP cores involves seven Sm proteins (D1/D2/F/E/G/D3/B) forming a ring around snRNA, typically requiring essential assembly chaperones like the SMN complex, associated with spinal muscular atrophy (SMA). Strikingly, in
Yingzhi Wang +12 more
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Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein [PDF]
, 2002 Cindy L. Will
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Addressing the tissue specificity of U5 snRNP spliceosomopathies
Frontiers in Cell and Developmental BiologyPrecursor mRNA (pre-mRNA) must undergo splicing to remove intron sequences and join exons. This splicing process is catalysed by an RNA/protein complex called the spliceosome.
Rahmat Azhari Kemal +2 more
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Methylosome and SMN complexes are dispensable for snRNP assembly in Arabidopsis [PDF]
, 2023 Daniela Goretti +3 more
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Nature CommunicationsExpansion of RNA polymerase III (Pol III) activity in cancer can activate the transcription of typically silent small RNA genes, including snaR-A (small NF90-associated RNA isoform A), a hominid-specific noncoding RNA that promotes cell proliferation ...
Sihang Zhou +7 more
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