Results 21 to 30 of about 13,335 (199)

U1 snRNP-Dependent Suppression of Polyadenylation: Physiological Role and Therapeutic Opportunities in Cancer

International Journal of Cell Biology, 2013
Pre-mRNA splicing and polyadenylation are critical steps in the maturation of eukaryotic mRNA. U1 snRNP is an essential component of the splicing machinery and participates in splice-site selection and spliceosome assembly by base-pairing to the 5 ...
Lee Spraggon, Luca Cartegni
doaj   +1 more source

Transcription Factors Mediate the Enzymatic Disassembly of Promoter-Bound 7SK snRNP to Locally Recruit P-TEFb for Transcription Elongation

Cell Reports, 2013
The transition from transcription initiation into elongation is controlled by transcription factors, which recruit positive transcription elongation factor b (P-TEFb) to promoters to phosphorylate RNA polymerase II.
Ryan P. McNamara, Jennifer L. McCann, Swapna Aravind Gudipaty, Iván D’Orso   +3 more
doaj   +1 more source

U5 snRNP Core Proteins Are Key Components of the Defense Response against Viral Infection through Their Roles in Programmed Cell Death and Interferon Induction

Viruses, 2022
The spliceosome is a massive ribonucleoprotein structure composed of five small nuclear ribonucleoprotein (snRNP) complexes that catalyze the removal of introns from pre-mature RNA during constitutive and alternative splicing. EFTUD2, PRPF8, and SNRNP200
Simon Boudreault, Guy Lemay, Martin Bisaillon   +2 more
doaj   +1 more source

The CUGBP2 splicing factor regulates an ensemble of branchpoints from perimeter binding sites with implications for autoregulation [PDF]

, 2009
Alternative pre-mRNA splicing adjusts the transcriptional output of the genome by generating related mRNAs from a single primary transcript, thereby expanding protein diversity.
Dembowski, JA, Grabowski, PJ
core   +5 more sources

Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities

Nature Communications, 2017
The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional ...
Allison L. Didychuk, Eric J. Montemayor, Tucker J. Carrocci, Andrew T. DeLaitsch, Stefani E. Lucarelli, William M. Westler, David A. Brow, Aaron A. Hoskins, Samuel E. Butcher   +8 more
doaj   +1 more source

Interaction of eukaryotic translation initiation factor 4G with the nuclear cap-binding complex provides a link between nuclear and cytoplasmic functions of the m7 guanosine cap [PDF]

, 2001
In eukaryotes the majority of mRNAs have an m7G cap that is added cotranscriptionally and that plays an important role in many aspects of mRNA metabolism.
Afonina E., Boisvert F. M., Bushell M., Carmo-Fonseca M., Cho E. J., Dostie J., Dostie J., Ferreira J. A., Flaherty S. M., Fornerod M., Fortes P., Fortes P., Fraser C. S., Fromont-Racine M., Fu X. D., Gingras A. C., Gorlich D., Hentze M., Ho C. K., Izaurralde E., Izaurralde E., Jarmolowski A., Kataoka N., Kim C. Y., Kudo N., Le Hir H., Le Hir H., Lewis J. D., Lewis J. D., Lewis J. D., Lewis J. D., Martins L. M., McCracken S., Milligan J. F., Morley S. J., Morley S. J., Neugebauer K. M., Neugebauer K. M., Ohno M., Pettersson I., Piron M., Ponting C. P., Preiss T., Rozen F., Salditt-Georgieff M., Schaegger H., Shatkin A. J., Stade K., Visa N., Watanabe M., Zhou Z.   +50 more
core   +2 more sources

Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs.

PLoS ONE, 2007
Spinal muscular atrophy (SMA) is a motor neuron disease caused by reduced levels of the survival motor neuron (SMN) protein. SMN together with Gemins2-8 and unrip proteins form a macromolecular complex that functions in the assembly of small nuclear ...
Francesca Gabanella, Matthew E R Butchbach, Luciano Saieva, Claudia Carissimi, Arthur H M Burghes, Livio Pellizzoni   +5 more
doaj   +1 more source

Role of Cajal bodies and nucleolus in the maturation of the U1 snRNP in Arabidopsis. [PDF]

PLoS ONE, 2008
BACKGROUND: The biogenesis of spliceosomal snRNPs takes place in both the cytoplasm where Sm core proteins are added and snRNAs are modified at the 5' and 3' termini and in the nucleus where snRNP-specific proteins associate.
Zdravko J Lorković, Andrea Barta
doaj   +1 more source

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Ahn, Aitken, Alexander, Alexander, Batsché, Bentley, Buratowski, Carrillo Oesterreich, Chapman, Chen, Cho, Cordin, Cramer, Damgaard, Das, David, de Almeida, Dönmez, Edgar, Egloff, Fong, Furger, Görnemann, Hirose, J. David Barrass, Jean D. Beggs, Ji, Kameoka, Keerthi T. Chathoth, Komarnitsky, Kornblihtt, Kornblihtt, Kosowski, Lacadie, Levine, Li, Lin, McCracken, McKay, Miller, Moore, Orphanides, Perriman, Perriman, Perriman, Perriman, Pleiss, Ruby, Schmidt, Schneider, Schroeder, Shao, Shaun Webb, Singh, Tardiff, Wahl, Wells, Witten, Xu, Xu, Yan, Zavanelli, Zhou   +62 more
core   +1 more source

CryoEM structure of Saccharomyces cerevisiae U1 snRNP offers insight into alternative splicing

Nature Communications, 2017
U1 snRNP is critical for 5′ splicing site recognition in pre-mRNA splicing. Here the authors describe the cryo-EM structure of the yeast U1 snRNP and suggest that PrpF39 is an alternative splicing factor essential for the successful recruitment of U1 ...
Xueni Li, Shiheng Liu, Jiansen Jiang, Lingdi Zhang, Sara Espinosa, Ryan C. Hill, Kirk C. Hansen, Z. Hong Zhou, Rui Zhao   +8 more
doaj   +1 more source