Results 71 to 80 of about 13,335 (199)

Structure of a transcribing Pol II-DSIF-SPT6-U1 snRNP complex

Nature Communications
In eukaryotic cells, splicing occurs predominantly co-transcriptionally, enhancing splicing efficiency and fidelity while introducing an additional layer of regulation over gene expression.
Luojia Zhang, Christopher Batters, Shintaro Aibara, Yuliya Gordiyenko, Kristina Žumer, Jana Schmitzová, Kerstin Maier, Patrick Cramer, Suyang Zhang   +8 more
doaj   +1 more source

Pathogenesis of proximal autosomal recessive spinal muscular atrophy [PDF]

, 2008
Although it is known that deletions or mutations of the SMN1 gene on chromosome 5 cause decreased levels of the SMN protein in subjects with proximal autosomal recessive spinal muscular atrophy (SMA), the exact sequence of pathological events leading to ...
Šimić, Goran
core   +1 more source

Transcriptome Differentiation of Wild and Hatchery‐Reared Gibelion catla Fish in Bangladesh

Aquaculture, Fish and Fisheries, Volume 6, Issue 1, February 2026.
ABSTRACT Transcriptome differences between wild and hatchery‐reared Gibelion catla collected from Halda (HL) and Padma River (PD) as wild and a hatchery (HR) population in Bangladesh were identified in this study. A total of 6780 differentially expressed genes (DEGs) in HL compared to HR indicated significant variations in gene expression consistent ...
Shumaya Shafrin, Md. Alamgir Kabir, Md. Golam Rabbane   +2 more
wiley   +1 more source

Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction

Frontiers in Molecular Biosciences, 2017
Spinal Muscular Atrophy (SMA) is a neuromuscular disorder that results from decreased levels of the survival motor neuron (SMN) protein. SMN is part of a multiprotein complex that also includes Gemins 2–8 and Unrip. The SMN-Gemins complex cooperates with
Maia Lanfranco, Maia Lanfranco, Maia Lanfranco, Neville Vassallo, Neville Vassallo, Ruben J. Cauchi, Ruben J. Cauchi   +6 more
doaj   +1 more source

RNA-Seq analysis of splicing in Plasmodium falciparum uncovers new splice junctions, alternative splicing and splicing of antisense transcripts. [PDF]

, 2011
Over 50% of genes in Plasmodium falciparum, the deadliest human malaria parasite, contain predicted introns, yet experimental characterization of splicing in this organism remains incomplete.
DeRisi, Joseph L, Dimon, Michelle T, Sorber, Katherine   +2 more
core   +3 more sources

A Novel N‐Terminal PRPF6 Variant in Autosomal Dominant Retinitis Pigmentosa

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT This report identifies the first N‐terminal PRPF6 variant (c.514C>T) as a cause of autosomal dominant Retinitis Pigmentosa. This novel variant is associated with progressive peripheral vision loss but notably preserved central visual acuity, suggesting a distinct phenotypic expression compared to C‐terminal variants.
Na Li, Yalong Dang
wiley   +1 more source

Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

Cell Reports
Summary: Triple negative breast cancer (TNBC) is an aggressive type of breast cancer. While most TNBCs are initially sensitive to chemotherapy, a substantial fraction acquires resistance to treatments and progresses to more advanced stages.
Cinzia Caggiano, Valerio Petrera, Miriana Ferri, Marco Pieraccioli, Eleonora Cesari, Alba Di Leone, Martin Alejandro Sanchez, Alessandra Fabi, Riccardo Masetti, Chiara Naro, Claudio Sette   +10 more
doaj   +1 more source

HMGA1a Induces Alternative Splicing of the Estrogen Receptor-αlpha Gene by Trapping U1 snRNP to an Upstream Pseudo-5′ Splice Site

Frontiers in Molecular Biosciences, 2018
Objectives: The high-mobility group A protein 1a (HMGA1a) protein is known as a transcription factor that binds to DNA, but recent studies have shown it exerts novel functions through RNA-binding.
Kenji Ohe, Shinsuke Miyajima, Tomoko Tanaka, Yuriko Hamaguchi, Yoshihiro Harada, Yuta Horita, Yuki Beppu, Fumiaki Ito, Takafumi Yamasaki, Hiroki Terai, Masayoshi Mori, Yusuke Murata, Makito Tanabe, Ichiro Abe, Kenji Ashida, Kunihisa Kobayashi, Munechika Enjoji, Takashi Nomiyama, Toshihiko Yanase, Nobuhiro Harada, Toshiaki Utsumi, Akila Mayeda   +21 more
doaj   +1 more source

U2 snRNP is required for expression of the 3' end of genes. [PDF]

PLoS ONE, 2014
Pre-mRNA in eukaryotes is subjected to mRNA processing, which includes capping, polyadenylation, and splicing. Transcription and mRNA processing are coupled, and this coupling stimulates mRNA processing; however, the effects of mRNA processing on ...
Mitsunori Koga, Takayuki Satoh, Ichiro Takasaki, Yumi Kawamura, Minoru Yoshida, Daisuke Kaida   +5 more
doaj   +1 more source

Gezielte Modulation des spliceosomalen Proteins USP39 durch allosterische Liganden und PROTAC‐induzierte Degradation

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Proteolysis‐targeting Chimeras (PROTACs) ermöglichen die gezielte Degradation bislang als „undruggable“ geltende Proteine über das zelluläre Ubiquitin–Proteasom‐System. In dieser Studie identifizieren Schäfer et al. thiazolbasierte niedermolekulare Liganden, die allosterisch an die Zinkfinger‐Domäne der Ubiquitin‐spezifischen Protease 39 (USP39) binden
Daniel Schäfer, Cristian Prieto‐Garcia, Jianhui Wang, Marcel Heinz, Vigor Matkovic, Pavel Kielkowski, Sebastian Hasselbeck, Varun Jayeshkumar Shah, Stefan Knapp, Gerhard Hummer, Ivan Dikic, Xinlai Cheng   +11 more
wiley   +1 more source