SOAT1 in ovarian cancer cells regulates immune response mediated by CD8+ T cells [PDF]
Journal of Ovarian ResearchBackground Sterol-O acyltransferase 1 (SOAT1) functions by converting cholesterol and acyl-CoA into cholesterol ester and CoA-SH. SOAT1 inhibition suppresses tumor growth.
Jiangnan He +8 more
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N4-acetylcytidine-mediated SOAT1 upregulation aggravates heart failure by inducing NCOA4-dependent ferroautophagy and ferroptosis in cardiomyocytes [PDF]
Cellular and Molecular Life SciencesHeart failure (HF) remains a critical global health challenge, with accumulating evidence implicating iron metabolism dysregulation through ferritinophagy activation in disease progression.
Jizhao Deng, Xiting Nong, Guang Yang
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p53-SOAT1 Axis: A Novel Target for Tumor Lipid Metabolism and Therapy [PDF]
Chinese Journal of Lung CancerCancer treatment is a significant challenge facing global medicine, with complex molecular mechanisms and drug resistance being key factors limiting treatment outcomes.
Xi YU +5 more
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Epigenetic dysregulation of steroidogenesis and neuroactive steroid deficiency in premature ovarian insufficiency: implications for neurodegenerative risk [PDF]
Biomarker ResearchPremature ovarian insufficiency (POI) is associated with an increased risk of neurodegenerative diseases, but the underlying mechanisms remain unclear.
Qian Wang +8 more
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Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion [PDF]
Breast Cancer ResearchSignaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results in enhanced proliferation, migration, and invasion of tumor cells.
Jennifer E. Tuokkola +6 more
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Nuclear envelope-associated lipid droplets are enriched in cholesteryl esters and increase during inflammatory signaling [PDF]
The EMBO JournalCholesteryl esters (CEs) and triacylglycerols (TAGs) are stored in lipid droplets (LDs), but their compartmentalisation is not well understood.
Ábel Szkalisity +10 more
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Exploring plasticisers-osteoporosis links and mechanisms: a cohort and network toxicology study [PDF]
Frontiers in ToxicologyBackgroundPlasticisers, widely present in daily life, have been linked to osteoporosis (OP), though the precise mechanisms remain unclear.MethodsThis study examined the association between mono (2-ethylhexyl) phthalate (MEHP) and OP using multivariate ...
Xingyao Yang +6 more
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SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma [PDF]
Cell Death and DiseaseCholesterol metabolism reprogramming is one of the significant characteristics of hepatocellular carcinoma (HCC). Cholesterol increases the risk of epithelial–mesenchymal transition (EMT) in cancer.
Rongrong Fu +7 more
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Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lines and cerebral organoids [PDF]
Communications BiologyViruses depend on host metabolic pathways and flaviviruses are specifically linked to lipid metabolism. During dengue virus infection lipid droplets are degraded to fuel replication and Zika virus (ZIKV) infection depends on triglyceride biosynthesis ...
Anja Schöbel +7 more
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TsR-0072 inhibits colorectal cancer progression through modulating lipid and vitamin D3 metabolic reprogramming and inactivating the Wnt/β-catenin signalling pathway [PDF]
Annals of MedicineBackground tRNA-derived small RNAs (tsRNAs), newly developed non-coding RNAs with specialized biological features, are aberrantly expressed in the majority of malignancies.
Qianyi Qi +8 more
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