Results 101 to 110 of about 2,949 (185)
Emerging Fusarium and Alternaria mycotoxins : occurrence, toxicity and toxicokinetics [PDF]
, 2017 Emerging Fusarium and Alternaria mycotoxins gain more and more interest due to their frequent contamination of food and feed, although in vivo toxicity and toxicokinetic data are limited.
Antonissen, Gunther +3 more
core +3 more sources
Liver X receptor inhibition potentiates mitotane induced adrenotoxicity in ACC [PDF]
, 2020 Adrenocortical carcinoma (ACC) is a rare aggressive malignancy with a poor outcome largely due to limited treatment options. Here, we propose a novel therapeutic approach through modulating intracellular free cholesterol via the liver X receptor alpha ...
Chatterjee, V Krishna +10 more
core +2 more sources
Acta Physiologica, Volume 241, Issue 8, August 2025.ABSTRACT Aim Podocytes, highly specialized epithelial cells located in the glomerulus of the kidney, are essential to the filtration barrier that ensures separation of blood and urine. These cells exhibit a unique architecture, characterized by an intricate network of foot processes interconnected by slit diaphragms, which serve as a critical selective
Desiree Loreth +2 more
wiley +1 more source
Mitochondria‐Associated Endoplasmic Reticulum Membranes in Human Health and Diseases
MedComm, Volume 6, Issue 7, July 2025.MAM dysfunction is considered as an initiator or contributor in the progression of various diseases such as nervous system diseases, circulatory system diseases, digestive system diseases, locomotor system diseases, reproductive system diseases, endocrine system diseases, urinary system diseases, respiratory system diseases and cancer.
Yong Liu +10 more
wiley +1 more source
Association study of cholesterol-related genes in Alzheimer's disease [PDF]
, 2018 Alzheimer's disease (AD) is a genetically complex disorder, and several genes related to cholesterol metabolism have been reported to contribute to AD risk.
Barcikowska, Maria +27 more
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Searching for neutral lipid regulators in mammalian cells from natural resources [PDF]
, 2023 北里大学博士（薬科学）2022(令和4)年度doctoral ...
NUR, Elyza Aiman Azizah +1 more
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CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.PRPF40B promotes circMAN1A2 expression, inhibiting TEP1‐KEAP1 complex formation, leading to NRF2 degradation and ferroptosis in GSCs. Without circMAN1A2, NRF2 activation inhibits ferroptosis and promotes TAMs' M2 polarization. ABSTRACT Background Glioblastoma (GBM) is a highly aggressive brain tumor with poor prognosis and resistance to temozolomide ...
Xinqiao Li +7 more
wiley +1 more source
Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents [PDF]
, 2011 Background Protein and mRNA levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency.
Anna M Raines, Roger A Sunde
core +1 more source
Cancer Medicine, Volume 14, Issue 10, May 2025.ABSTRACT Background Gastrointestinal malignancies are a major public health concern worldwide, characterized by high incidence and mortality rates. Despite continuous advancements in existing treatment methods, overall survival rates remain low. Lipid metabolism plays a crucial role in the occurrence, progression, and treatment of gastrointestinal ...
Yan An +4 more
wiley +1 more source
The Cutaneous Lesions of Dioxin Exposure: Lessons from the Poisoning of Victor Yushchenko [PDF]
, 2017 Several million people are exposed to dioxin and dioxin-like compounds, primarily through food consumption. Skin lesions historically called "chloracne” are the most specific sign of abnormal dioxin exposure and classically used as a key marker in humans.
Barde, Caroline +15 more
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