Results 111 to 120 of about 2,949 (185)

A simple method to disrupt and restore subunit interaction of acyl-CoA:cholesterol acyltransferase 1

MethodsX, 2019
Acyl-CoA:cholestereol acyltransferase 1 (ACAT1) is a two-fold dimer (homotetramer) and has two distinct dimerization domains. One domain is in an alpha-helical rich region near the cytoplasmic N-terminus.
Bryan Neumann, Catherine C.Y. Chang, Ta-Yuan Chang   +2 more
doaj   +1 more source

Expression of components involved in cholesterol homeostasis maintenance during experimental autoimmune encephalomyelitis in rat spinal cord

Folia Neuropathologica
Dysregulations in cholesterol homeostasis contribute to the pathogenesis of multiple sclerosis (MS) and its best described animal model, experimental autoimmune encephalomyelitis (EAE).
Smilja Todorovic, Katarina Milosevic, Ana Milosevic, Marija M. Janjic, Srdjan J. Sokanovic, Danijela Savic, Irena Lavrnja   +6 more
doaj   +1 more source

Control of ACAT2 liver expression by HNF1

Journal of Lipid Research, 2005
ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty acids. There are two known genes encoding the two ACAT enzymes, ACAT1 and ACAT2 (also known as Soat1 and Soat2).
Camilla Pramfalk, Matthew A. Davis, Mats Eriksson, Lawrence L. Rudel, Paolo Parini   +4 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 19, Issue S1, Page 1-940, June 2025.
Abstracts submitted to the ‘EACR 2025 Congress: Innovative Cancer Science’, from 16–19 June 2025 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Integrated analysis of transcript-level regulation of metabolism reveals disease-relevant nodes of the human metabolic network [PDF]

, 2017
Metabolic diseases and comorbidities represent an ever-growing epidemic where multiple cell types impact tissue homeostasis. Here, the link between the metabolic and gene regulatory networks was studied through experimental and computational analysis ...
Berninger, Philipp, Galhardo, Mafalda, Heinäniemi, Merja, Lin, Jake, Sauter, Thomas, Sinkkonen, Lasse   +5 more
core  

SOAT1: A Suitable Target for Therapy in High-Grade Astrocytic Glioma? [PDF]

Targeting molecular alterations as an effective treatment for isocitrate dehydrogenasewildtype glioblastoma (GBM) patients has not yet been established.
Bohnert, Simone, Hundt, Jennifer Elisabeth, Härtig, Wolfgang, Janaki-Raman, Sudha, Kircher, Stefan, Kroiß, Matthias, Lapa, Constantin, Löhr, Mario, Mages, Bianca, Monoranu, Camelia-Maria, Sbiera, Silviu, Schulze, Almut, Strobel, Sabrina   +12 more
core   +1 more source

The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Cells
Vascular smooth muscle cells (VSMCs), in their contractile and differentiated state, are fundamental for maintaining vascular function. Upon exposure to cholesterol (CHO), VSMCs undergo dedifferentiation, adopting characteristics of foam cells—lipid ...
Bethany J. Bogan, Holly C. Williams, Claire M. Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W. Robert Taylor, Amir Rezvan, Alejandra San Martin   +9 more
doaj   +1 more source

Sterol O-Acyltransferase 1 (SOAT1): A Genetic Modifier of Niemann-Pick Disease, Type C1

International Journal of Molecular Sciences
Niemann-Pick disease type C1 (NPC1) is a lysosomal disorder due to impaired intracellular cholesterol transport out of the endolysosomal compartment. Marked heterogeneity has been observed in individuals with the same NPC1 genotype, thus suggesting a significant effect of modifier genes.
Nicole Y. Farhat, Derek Alexander, Kyli McKee, James Iben, Jorge L. Rodriguez-Gil, Christopher A. Wassif, Niamh X. Cawley, William E. Balch, Forbes D. Porter   +8 more
openaire   +2 more sources

Identification of gene signatures and molecular mechanisms underlying the mutual exclusion between psoriasis and leprosy

Scientific Reports
Leprosy and psoriasis rarely coexist, the specific molecular mechanisms underlying their mutual exclusion have not been extensively investigated. This study aimed to reveal the underlying mechanism responsible for the mutual exclusion between psoriasis ...
You-Wang Lu, Rong-Jing Dong, Lu-Hui Yang, Jiang Liu, Ting Yang, Yong-Hong Xiao, Yong-Jun Chen, Rui-Rui Wang, Yu-Ye Li   +8 more
doaj   +1 more source

Colonist, 1887-09-28 [PDF]

, 1887
The Colonist began on 6 March 1886, changing its name to The Newfoundland Colonist after 18 July 1891. Having printed local and international news Monday to Saturday for six years, the paper came to an abrupt end when its offices were destroyed in The ...

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