Results 121 to 130 of about 2,949 (185)

A Database Tool Integrating Genomic and Pharmacologic Data from Adrenocortical Carcinoma Cell Lines, PDX, and Patient Samples [PDF]

Adrenocortical carcinoma (ACC) is a rare and highly heterogeneous disease with a notably poor prognosis due to significant challenges in diagnosis and treatment.
Abate, Andrea, Arakawa, Yasuhiro, Berruti, Alfredo, Boeva, Valentina, Del Rivero, Jaydira, Elloumi, Fathi, Gottesman, Michael M, Hantel, Constanze, Jo, Ukhyun, Khandagale, Prashant, Kiseljak-Vassiliades, Katja, Kumar, Suresh, Pommier, Yves, Reinhold, William C, Robey, Robert W, Roper, Nitin, Sigala, Sandra, Takebe, Naoko, Tamburello, Mariangela, Thomas, Craig J, Varma, Sudhir, Weigand, Isabel, Wierman, Margaret E   +22 more
core   +1 more source

Plasma fatty acids and expression of genes related to lipid metabolism [PDF]

, 2016
Master i samfunnsernæringBackground: The amount and type of fatty acids in the diet may influence the pathogenesis of cardiovascular disease. Fatty acids is known to modulate the expression of genes, which could have an impact on cardiovascular disease ...
Dagsland, Kine Næss
core  

The effects of age and dysfunction on meibomian gland population dynamics. [PDF]

PURPOSE: While meibomian gland dysfunction (MGD) is widely recognized as a major cause of evaporative dry eye disease, little is known about normal gland differentiation and lipid synthesis or the mechanism underlying gland atrophy and abnormal lipid ...
Andersen, Bogi, Jester, James, Kashgari, Ghaidaa, Knickelbein, Kelly, Lane, Shelley, Leonard, Brian, Wiedemann, Julie   +6 more
core   +1 more source

Identifying Critical Genes for Cholesterol Metabolism in Macrophages Using CRISPR-Cas9 Whole-Genome Screens [PDF]

, 2019
Macrophage foam cells contribute to atherosclerotic plaque formation, a pathology that underlies heart disease, peripheral arterial disease and stroke. Foam cells form when macrophages take up excessive amounts of low-density lipoprotein (LDL) leading to
Wanniarachchi, Kevin
core   +1 more source

Sterol O-aceyltransferase 1 (SOAT1; ACAT1) [PDF]

Science-Business eXchange, 2014
openaire   +1 more source

Gene loss in Antarctic icefish: evolutionary adaptations mimicking Fanconi Anemia?

BMC Genomics
Background The white-blooded Antarctic icefishes is a representative organism that survive under the stenothermal conditions of the Southern Ocean without the hemoglobin genes.
Seung Chul Shin, Sanghee Kim, Han-Woo Kim, Jun Hyuck Lee, Jin-Hyoung Kim   +4 more
doaj   +1 more source

Sterol O-acyltransferase 1 (SOAT1; ACAT1) [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Hoxc13 regulation of Soat1 in the hippocampus and cerebellum

Developmental Biology, 2009
Potter, Christopher S., Potter, Kathleen A., Pruett, Nathanael D., Kern, Michael J., Godwin, Alan A., Sundberg, John P., Awgulewitsch, Alexander   +6 more
openaire   +1 more source

Targeting the Cholesterol Storage Enzyme ACAT1/SOAT1 in Brain Cells and Mouse Model: A Novel Approach to Address Aging and APOE4-Related Neuroinflammation [PDF]

Alzheimer’s Disease (AD) is a progressive neurodegenerative disease that significantly impacts nearly 7 million people in the United States. AD is characterized by the deposition of amyloid beta (Ab) plaque, tau neurofibrillary tangles (NFTs), lipids ...
Huynh Krumeich, Thao Nguyen Phuong
core   +1 more source

SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity. [PDF]

Cell Rep
Zhong Y, Mazik L, Su H, Chiang CY, Geng F, Mo X, Wang Q, Kou Y, Chen W, Li Z, Horbinski C, Chakravarti A, Wang QE, Guo D.   +13 more
europepmc   +1 more source