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Novel Role of AcylCoA:cholesterol acyltransferase 1 (ACAT1/SOAT1) in Diabetic Retinopathy

ABSTRACT Hypercholesterolemia and excessive cholesterol ester (CE) production have been linked to chronic inflammation and vascular dysfunction during cardiovascular disease. Upregulation of AcylCoA:cholesterol acyltransferase 1 (ACAT1/SOAT1), the enzyme responsible for retinal CE formation, has been implicated in pathological retinal ...
Syed Adeel H. Zaidi +8 more
openaire +1 more source

SOAT1 dysregulation in astrocytes drives Blood–Brain barrier dysfunction and neuroinflammation in Alzheimer’s disease

Brain, Behavior, and Immunity
Alzheimer's disease (AD) is a neurodegenerative disorder that leads to memory loss and cognitive decline, in which blood-brain barrier (BBB) and astrocyte dysfunction are significantly involved. Recent evidence suggests that dysregulation of lipid metabolism in astrocytes contributes to BBB disruption and neuroinflammation in AD.
Lian Huang +7 more
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TMET-15. SREBP-1 upregulates SOAT1 to promote tumor growth by preventing lipotoxicity

Neuro-Oncology
Abstract Rapidly growing tumors require a continuous supply of cholesterol, which is sustained by upregulating sterol regulatory element-binding protein 1 (SREBP-1), a master transcription factor that drives cholesterol uptake and biosynthesis. Unexpectedly, our current study revealed that sterol O-acyltransferase 1 (SOAT1), an enzyme
Yaogang Zhong +10 more
openaire +1 more source

Cholesterol trapping by SOAT1 induces mitochondrial cholesterol accumulation and decrease oxidative metabolism