Myeloid ACAT1/SOAT1: a novel regulator of dyslipidemia and retinal neovascularization [PDF]
npj Metabolic Health and DiseasePathological retinal neovascularization (RNV) is a major cause of vision loss and blindness during ischemic retinopathies. Our investigations in the mouse model of oxygen-induced retinopathy (OIR) demonstrate a novel mechanism of pathological RNV and ...
Syed A. H. Zaidi +2 more
doaj +3 more sources
SOAT1 Promotes Gastric Cancer Lymph Node Metastasis Through Lipid Synthesis [PDF]
Frontiers in Pharmacology, 2021 Emerging evidences demonstrate that metabolic reprogramming is a hallmark of malignancies, including gastric cancer (GC). Abnormal expression of metabolic rate-limiting enzymes, as the executive medium of energy metabolism, drives the occurrence and ...
Tingting Zhu +12 more
doaj +3 more sources
SOAT1 methylation is associated with coronary heart disease [PDF]
Lipids in Health and Disease, 2019 Background This study was designed to investigate whether differential DNA methylationin of cholesterol absorption candidate genes can function as a biomarker for patients with coronary heart disease (CHD). Methods DNA methylation levels of the candidate
Jialin Abuzhalihan +8 more
doaj +3 more sources
SOAT1: a suitable target for therapy in high-grade astrocytic glioma? [PDF]
International Journal of Molecular Sciences, 2022 Targeting molecular alterations as an effective treatment for isocitrate dehydrogenase-wildtype glioblastoma (GBM) patients has not yet been established.
Bohnert, Simone +12 more
core +6 more sources
SOAT1 missense variant in two cats with sebaceous gland dysplasia. [PDF]
Molecular Genetics and Genomics, 2023 Spontaneously arisen hereditary diseases in domestic animals provide an excellent opportunity to study the physiological functions of the altered genes. We investigated two 4-month-old sibling domestic short haired kittens with dry dark debris around the
Affolter, Verena K +6 more
core +6 more sources
Simultaneously targeting SOAT1 and CPT1A ameliorates hepatocellular carcinoma by disrupting lipid homeostasis [PDF]
Cell Death Discovery, 2021 Lipid homeostasis plays a fundamental role in the development of hepatocellular carcinoma (HCC). However, the mechanisms that regulate lipid homeostasis to avoid lipotoxicity in HCC remain elusive.
Meiling Ren +4 more
doaj +3 more sources
Identification of Soat1 as a quantitative trait locus gene on mouse chromosome 1 contributing to hyperlipidemia. [PDF]
PLoS ONE, 2011 We previously identified two closely linked quantitative trait loci (QTL) on distal chromosome 1 contributing to major variations in plasma cholesterol and triglyceride levels in an intercross derived from C57BL/6 (B6) and C3H/HeJ (C3H) apolipoprotein E ...
Zongji Lu +6 more
doaj +4 more sources
Cell Death and Disease, 2023 Glioma, the most common primary malignant tumor of the central nervous system, lacks effective targeted therapies. This study investigates the role of SOAT1, a key gene involved in cholesterol esterification, in glioma prognosis and its association with ...
Shicheng Sun +10 more
doaj +3 more sources
High-affinity SOAT1 ligands remodeled cholesterol metabolism program to inhibit tumor growth
BMC Medicine, 2022 Background Although cholesterol metabolism is a common pathway for the development of antitumor drugs, there are no specific targets and drugs for clinical use.
Zhihua Wang +10 more
doaj +3 more sources
Impacts of the SOAT1 genetic variants and protein expression on HBV-related hepatocellular carcinoma [PDF]
BMC Cancer, 2021 Background Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains a major public health problem and its pathogenesis remains unresolved.
Yulong Chen +6 more
doaj +3 more sources