Results 21 to 30 of about 2,949 (185)

Cholesterol activates the Wnt/PCP-YAP signaling in SOAT1-targeted treatment of colon cancer [PDF]

Cell Death Discovery, 2021
Intracellular free cholesterol can be converted to cholesteryl ester and stored as lipid droplets through SOAT1-mediated esterification. Compelling evidence implicate targeting SOAT1 as a promising therapeutic strategy for cancer management.
Huanji Xu, Hongwei Xia, Sheng Zhou, Qiulin Tang, Feng Bi   +4 more
doaj   +3 more sources

ACAT1/SOAT1 maintains adipogenic ability in preadipocytes by regulating cholesterol homeostasis

Journal of Lipid Research
Maintaining cholesterol homeostasis is critical for preserving adipocyte function during the progression of obesity. Despite this, the regulatory role of cholesterol esterification in governing adipocyte expandability has been understudied. Acyl-coenzyme
Qing Liu, Xiaolin Wu, Wei Duan, Xiaohan Pan, Martin Wabitsch, Ming Lu, Jing Li, Li-Hao Huang, Zhangsen Zhou, Yuyan Zhu   +9 more
doaj   +3 more sources

Integrative eQTL and Mendelian randomization analysis reveals key genetic markers in mesothelioma [PDF]

Respiratory Research
Background Mesothelioma is a rare cancer that originates from the pleura and peritoneum, with its incidence increasing due to asbestos exposure. Patients are frequently diagnosed at advanced stages, resulting in poor survival rates.
Jinsong Li, Xingmeng Wang, Yaru Lin, Zhengliang Li, Wei Xiong   +4 more
doaj   +2 more sources

SOAT1 exacerbates tumor progression by promoting YAP signaling activation and attenuating endoplasmic reticulum stress

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Metabolic reprogramming is a hallmark of malignancy, with profound alterations in cellular metabolism driving cancer progression. However, the precise mechanisms by which these metabolic changes promote tumor growth remain poorly understood.
Fan Wang, Qianyu Li, Yifei Qian, Yu Tong, Songling Li, Wenyun Guo, Linfeng Li, Zijun Zhu, Wei‐Qiang Gao, Yanfeng Liu   +9 more
doaj   +2 more sources

Cadmium-Induced Mitochondrial and MAMs Dysregulation in Rat Testis: The Protective Role of D-Aspartate. [PDF]

Environ Toxicol
ABSTRACT Cadmium (Cd), a heavy metal, disrupts the structure of seminiferous tubules and induces cell death at multiple stages of sperm development. Cd also impairs Leydig cells (LCs), resulting in reduced serum testosterone (T) levels. This study primarily examined the impact of Cd on the mitochondrial compartment and mitochondrial‐associated ...
Latino D, Falvo S, Venditti M, Santillo A, Grillo G, Chieffi Baccari G, Messaoudi I, Di Fiore MM.   +7 more
europepmc   +2 more sources

Embryonic cholesterol esterification is regulated by a cyclic AMP-dependent pathway in yolk sac membrane-derived endodermal epithelial cells. [PDF]

PLoS ONE, 2017
During avian embryonic development, endodermal epithelial cells (EECs) absorb yolk through the yolk sac membrane. Sterol O-acyltransferase (SOAT) is important for esterification and yolk lipid utilization during development.
Siou-Huei Wang, Han-Jen Lin, Yuan-Yu Lin, Yu-Jen Chen, Yu-Hui Pan, Cheng-Ting Tung, Harry John Mersmann, Shih-Torng Ding   +7 more
doaj   +1 more source

Sevoflurane attenuates proliferative and migratory activity of lung cancer cells via mediating the microRNA-100-3p/sterol O-Acyltransferase 1 axis

Chinese Journal of Physiology, 2023
Recently, evidence has shown that microRNA-100-3p (miR-100-3p) has been revealed as a tumor suppressor in diverse human diseases, while its capability in lung cancer warrants further validation. In this work, we aimed to discuss the impact of sevoflurane
Bicheng Fu, Fucheng Zhou, Jian Zhang, Xianglong Kong, Boxiong Ni, Jianlong Bu, Shidong Xu, Changjun He   +7 more
doaj   +1 more source

Comprehensive Analysis of Sterol O-Acyltransferase 1 as a Prognostic Biomarker and Its Association With Immune Infiltration in Glioma

Frontiers in Oncology, 2022
Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) is an essential target for metabolic therapy. However, the prognostic value of SOAT1 and its association with immune infiltration has not been fully elucidated. Using
Xuyang Guo, Xuyang Guo, Shaolong Zhou, Shaolong Zhou, Zhuo Yang, Zhuo Yang, Zi-An Li, Zi-An Li, Weihua Hu, Lirui Dai, Lirui Dai, Wulong Liang, Xinjun Wang, Xinjun Wang   +13 more
doaj   +1 more source

SOAT1 Activates NLRP3 Inflammasome to Promote Cancer-Related Lymphangiogenesis and Metastasis via IL-1β/IL-1R-1 Axis in Oral Squamous Cell Carcinoma. [PDF]

Mol Carcinog
ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Zhao C, Wang Y, Jiang Z, Guo S, Hu L, Pan J, Dan F.   +6 more
europepmc   +2 more sources

Generation and characterization of a mitotane-resistant adrenocortical cell line [PDF]

, 2020
Mitotane is the only drug approved for the therapy of adrenocortical carcinoma (ACC). Its clinical use is limited by the occurrence of relapse during therapy.
Bachmann, Sebastian, Bahethi, Rohini, Beule, Dieter, Choi, Murim, Eisenhofer, Graeme, Liebisch, Gerhard, Messerschmidt, Clemens, Obermayer, Benedikt, Peitzsch, Mirko, Scholl, Ute I., Schrade, Petra, Seidel, Eric, Walenda, Gudrun, Wallace, Paal, Yoo, Taekyeong   +14 more
core   +2 more sources