SOAT1 promotes mevalonate pathway dependency in pancreatic cancer
Journal of Experimental Medicine, 2020 Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and new therapies are needed. Altered metabolism is a cancer vulnerability, and several metabolic pathways have been shown to promote PDAC. However, the changes in cholesterol metabolism and their role during PDAC progression remain largely unknown.
Tobiloba E. Oni +20 more
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ACAT1/SOAT1 as a Therapeutic Target for Alzheimer's Disease [PDF]
Future Medicinal Chemistry, 2015 Alzheimer's disease (AD) is the most common cause of dementia with no cure at present. Cholesterol metabolism is closely associated with AD at several stages. ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis.
Yohei, Shibuya +2 more
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A pan-cancer analysis identifies SOAT1 as an immunological and prognostic biomarker
Oncology Research, 2023 Sterol o-acyltransferase1 (SOAT1) is an enzyme that regulates lipid metabolism. Nevertheless, the predictive value of SOAT1 regarding immune responses in cancer is not fully understood. Herein, we aimed to expound the predictive value and the potential biological functions of SOAT1 in pan-cancer.
HUANG, YANGQING +5 more
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piRNA-6426 increases DNMT3B-mediated SOAT1 methylation and improves heart failure
Aging, 2022 Previous studies found that piRNAs could participate in disease progression by regulating DNA methylation, but there are few reports on their roles in heart failure (HF).The level of piRNA-6426 in the venous blood of HF patients and volunteers was detected by RT-qPCR.
Zhong, Nier +3 more
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Targeting sterol-O-acyltransferase 1 to disrupt cholesterol metabolism for cancer therapy
Frontiers in Oncology, 2023 Cholesterol esterification is often dysregulated in cancer. Sterol O-acyl-transferase 1 (SOAT1) plays an important role in maintaining cellular cholesterol homeostasis by catalyzing the formation of cholesterol esters from cholesterol and long-chain ...
Teng Tu, Hongying Zhang, Huanji Xu
doaj +1 more source
Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study [PDF]
, 2010 Background Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer.
Rishikesh Mankidy +8 more
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Insights Into circRNA-Mediated Lipid Metabolism in Cancer Progression. [PDF]
J Cell Mol MedABSTRACT Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non‐coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been
Miao Z, Cao J, Wang X, Zhang C, Shi T.
europepmc +2 more sources
Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation [PDF]
, 2012 Background: Beneficial effects of omega-3 polyunsaturated fatty acids (n-3 PUFAs) on the lipid levels of dyslipidemic subjects are widely described in the literature. However, the underlying molecular mechanisms are largely unknown. The aim of this study
Hahn, Andreas +6 more
core +2 more sources
Circ-Tulp4 promotes β-cell adaptation to lipotoxicity by regulating soat1 expression [PDF]
Journal of Molecular Endocrinology, 2020 This study aimed to identify circular RNAs differentially expressed in the islets of type 2 diabetes (T2DM) models and clarify their roles in the control of β-cell functions. Circular RNAs dysregulated in the islets of diabetic db/db mice were identified by high-throughput RNA sequencing.
Wu, Liting +7 more
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A novel mechanism of action of HER2 targeted immunotherapy is explained by inhibition of NRF2 function in ovarian cancer cells [PDF]
, 2016 Nuclear erythroid related factor-2 (NRF2) is known to promote cancer therapeutic detoxification and crosstalk with growth promoting pathways. HER2 receptor tyrosine kinase is frequently overexpressed in cancers leading to uncontrolled receptor activation
Bown, James +6 more
core +3 more sources