Results 41 to 50 of about 2,949 (185)

Inhibition of Acyl-CoenzymeA: Cholesterol Acyltransferase 1 promotes shedding of soluble triggering receptor on myeloid cells 2 (TREM2) and low-density lipoprotein receptor 1 (LRP1)-dependent phagocytosis of amyloid beta protein in microglia. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Lipid regulation is crucial role in Alzheimer's disease (AD) pathogenesis. In AD, microglia show elevated sterol O‐acyltransferase 1/Acyl‐coenzymeA: Choleseterol Acyltransferase 1 (SOAT1) expression, encoding Acyl‐coenzymeA: Cholesterol Acyltransferase 1 (ACAT1), which produces cholesteryl esters (CEs) in lipid droplets ...
Hovde MJ, Maaser-Hecker A, Bae JS, Tanzi RE.   +3 more
europepmc   +2 more sources

Selective inhibition of sterolO-acyltransferase 1 isozyme by beauveriolide III in intact cells

Scientific Reports, 2017
Beauveriolide III (BeauIII) inhibited sterol O-acyltransferases 1 and 2 (SOAT1 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and selectively inhibited SOAT1 in a cell-based assay using SOAT1-/SOAT2-CHO ...
Taichi Ohshiro, Keisuke Kobayashi, Mio Ohba, Daisuke Matsuda, Lawrence L. Rudel, Takashi Takahashi, Takayuki Doi, Hiroshi Tomoda   +7 more
doaj   +1 more source

Eimeria bovis infection modulates endothelial host cell cholesterol metabolism for successful replication [PDF]

, 2015
During first merogony Eimeria bovis forms large macromeronts in endothelial host cells containing >120 000 merozoites I. During multiplication, large amounts of cholesterol are indispensable for the enormous offspring membrane production.
Gimpl, Gerald, Hamid, Penny H., Hermosilla, Carlos R., Hirzmann, Joerg, Kerner, Katharina, Lochnit, Guenter, Taubert, Anja   +6 more
core   +2 more sources

Direct comparison of distinct naive pluripotent states in human embryonic stem cells [PDF]

, 2017
Until recently, human embryonic stem cells (hESCs) were shown to exist in a state of primed pluripotency, while mouse embryonic stem cells (mESCs) display a naive or primed pluripotent state.
Chuva de Sousa Lopes, Susana Marina, De Coninck, Dieter, De Sutter, Petra, Deforce, Dieter, Duggal, Galbha, Heindryckx, Björn, Lierman, Sylvie, Menten, Björn, Mestdagh, Pieter, Peelman, Luc, Popovic, Mina, Sutherland, Ella, Taelman, Jasin, Tilleman, Laurentijn, Van der Jeught, Margot, Van Nieuwerburgh, Filip, Van Soom, Ann, Vandesompele, Jo, Warrier, Sharat   +18 more
core   +1 more source

AP-2α regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase [PDF]

, 2009
Background: Neuronal migration is a crucial process that allows neurons to reach their correct target location to allow the nervous system to function properly.
ORSO, FRANCESCA, Jager R, CALOGERO, Raffaele Adolfo, Schorle H, SISMONDI, Piero, DE BORTOLI, Michele, TAVERNA, Daniela   +6 more
core   +2 more sources

Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity

International Journal of Molecular Sciences, 2023
Cholesterol is a key component of all mammalian cell membranes. Disruptions in cholesterol metabolism have been observed in the context of various diseases, including neurodegenerative disorders such as Alzheimer’s disease (AD). The genetic and pharmacological blockade of acyl-CoA:cholesterol acyltransferase 1/sterol O-acyltransferase 1 (ACAT1/SOAT1 ...
Taylor C. Harned, Radu V. Stan, Ze Cao, Rajarshi Chakrabarti, Henry N. Higgs, Catherine C. Y. Chang, Ta Yuan Chang   +6 more
openaire   +2 more sources

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium [PDF]

, 2012
Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression ...
Bauersachs, Stefan, Büttner, Mathias, Meyer, Heinrich H. D., Minten, Megan, Reichenbach, Horst-Dieter, Reichenbach, Myriam, Sax, Gerhard, Spencer, Thomas E., Ulbrich, Susanne E., Winter, Gerhard, Wolf, Eckhard   +10 more
core   +1 more source

Acyl-Coenzyme A: Cholesterol Acyltransferase (ACAT) in Cholesterol Metabolism: From Its Discovery to Clinical Trials and the Genomics Era

Metabolites, 2021
The purification and cloning of the acyl-coenzyme A: cholesterol acyltransferase (ACAT) enzymes and the sterol O-acyltransferase (SOAT) genes has opened new areas of interest in cholesterol metabolism given their profound effects on foam cell biology and
Qimin Hai, Jonathan D. Smith
doaj   +1 more source

Physiological Effects of Soat1 Inactivation on Homeostasis of the Mouse Ocular Surface. [PDF]

Invest Ophthalmol Vis Sci
Soat1/SOAT1 have been previously reported to be critical for the biosynthesis of cholesteryl esters (CEs) in the mouse Meibomian glands (MGs) as the loss of function led to an arrest of CE production and a substantial accumulation of nonesterified cholesterol in the meibum, causing an increase in its melting temperature.
Wilkerson A, Yuksel S, Acharya R, Butovich IA.   +3 more
europepmc   +3 more sources

DAX-1 (NR0B1) and steroidogenic factor-1 (SF-1, NR5A1) in human disease. [PDF]

, 2015
DAX-1 (NR0B1) and SF-1 (NR5A1) are two nuclear receptor transcription factors that play a key role in human adrenal and reproductive development. Loss of DAX-1 function is classically associated with X-linked adrenal hypoplasia congenita.
Achermann, JC, Buonocore, F, Duncan, AJ, Suntharalingham, JP   +3 more
core   +1 more source