Animals, 2021 Honokiol (HON) is one of the main biological active components of the traditional Chinese medicine Magnolia officinalis and has many health benefits.
Yanan Ding +6 more
doaj +1 more source
Pathway-Wide Association Study Implicates Multiple Sterol Transport and Metabolism Genes in HDL Cholesterol Regulation [PDF]
, 2011 Pathway-based association methods have been proposed to be an effective approach in identifying disease genes, when single-marker association tests do not have sufficient power.
Kai eWang +18 more
core +1 more source
Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1–Mediated Lipogenesis [PDF]
Clinical Cancer Research, 2016 Abstract Purpose: Elevated lipogenesis regulated by sterol regulatory element-binding protein-1 (SREBP-1), a transcription factor playing a central role in lipid metabolism, is a novel characteristic of glioblastoma (GBM). The aim of this study was to identify effective approaches to suppress GBM growth by inhibition of SREBP-1.
Geng, Feng +18 more
openaire +3 more sources
The Pathophysiology and Treatment of Hypertension in Patients With Cushing's Syndrome [PDF]
, 2019 When hypertension, a pathology that is frequently found in the general population, presents in a young patient, secondary causes such as Cushing's syndrome (CS), a rare disease characterized by long-term elevated cortisol levels, should be considered ...
Barbot, Mattia +2 more
core +1 more source
Specific subdomain localization of ER resident proteins and membrane contact sites resolved by electron microscopy [PDF]
, 2021 The endoplasmic reticulum (ER) is a large, single-copy, membrane-bound organelle that comprises an elaborate 3D network of diverse structural subdomains, including highly curved tubules, flat sheets, and parts that form contacts with nearly every other ...
Belevich, Ilya +6 more
core +1 more source
How to Increase Users' Social Commerce Engagement? A Technology Attractiveness Model [PDF]
, 2017 With the proliferation of social networking and electronic commerce, social commerce helps people engage in various forms of online social commercial activities through sharing their product or service knowledge and experiences. A better understanding of
Chen, Zhenjiao +5 more
core +1 more source
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease
Molecular Medicine, 2022 Background Lipid accumulation in tubular cells plays a key role in diabetic kidney disease (DKD). Targeting lipid metabolism disorders has clinical value in delaying the progression of DKD, but the precise mechanism by which molecules mediate lipid ...
Chanyue Zhao +14 more
doaj +1 more source
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
iScience, 2021 Summary: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of kidney cancer and has high heterogeneity. Stratification of ccRCC is important since distinct subtypes differ in prognosis and treatment.
Xiangyu Li +12 more
doaj +1 more source
Differential gene expression profiles of hepatocellular carcinomas associated or not with viral infection [PDF]
, 2009 Chronic hepatitis B (HBV) and C (HCV) virus infections are the most important factors associated with hepatocellular carcinoma (HCC), but tumor prognosis remains poor due to the lack of diagnostic biomarkers. In order to identify novel diagnostic markers
ALVES, V.A.F. +9 more
core +2 more sources
Accumulation and aberrant composition of cholesteryl esters in Scrapie-infected N2a cells and C57BL/6 mouse brains [PDF]
, 2011 Objective: Cholesterol changes have been described in prion-cell models and in experimental rodent scrapie; yet,the pattern of this association is still controversial.
Sarah Vascellari +7 more
core +2 more sources