Results 61 to 70 of about 2,949 (185)
Mitotane Targets Lipid Droplets to Induce Lipolysis in Adrenocortical Carcinoma [PDF]
, 2022 INTRODUCTION Adrenocortical carcinoma (ACC) is a rare aggressive cancer with low overall survival. Adjuvant mitotane improves survival but is limited by poor response rates and resistance. Mitotane's efficacy is attributed to the accumulation of toxic
Beuschlein, Felix +6 more
core +1 more source
The Efficacy of Mitotane in Human Primary Adrenocortical Carcinoma Cultures [PDF]
, 2020 CONTEXT: Patients with adrenocortical carcinoma (ACC) often fail mitotane treatment and deal with severe toxicity, marking the relevance of predictive parameters for treatment outcome. OBJECTIVE: Determine the effects of mitotane in primary ACC cultures,
Creemers, S.G. (Sara) +6 more
core +3 more sources
JCI Insight, 2022 Colorectal cancer (CRC) severely threatens human health and life span. An effective therapeutic strategy has not been established because we do not clearly know its pathogenesis.
Yahui Zhu +10 more
doaj +1 more source
Cell Death Discovery, 2022 Colorectal cancer (CRC) is the third most common malignancy worldwide. Circular RNAs (circRNAs) have been reported to play critical regulatory roles in tumorigenesis, serving as tumor biomarkers and therapeutic targets.
Ruoqin Wang +10 more
doaj +1 more source
Transcriptional interference by RNA polymerase III affects expression of the Polr3e gene. [PDF]
, 2017 Overlapping gene arrangements can potentially contribute to gene expression regulation. A mammalian interspersed repeat (MIR) nested in antisense orientation within the first intron of the Polr3e gene, encoding an RNA polymerase III (Pol III) subunit, is
Cousin, P. +3 more
core +1 more source
Biomolecules, 2021 The association between intratumoral cholesteryl ester (CE) and tumor progression has been reported previously. The objective of our study was to investigate a causal effect of CE on mammary tumor progression. Using MMTV-PyMT (MMTV-polyoma virus middle T)
Lengyun Wei +4 more
doaj +1 more source
Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species [PDF]
, 2016 Genes mapped on Fig. 3.
Akihito Yasuoka +10 more
core +4 more sources
Die Rolle der Cyclin-abhängigen Kinase 18 (CDK18) im klarzelligen Nierenzellkarzinom [PDF]
, 2021 The most common and one of the more aggressive types of kidney cancer is clear cell renal cell carcinoma. It is characterized by sporadic occurrence, poor prognosis, and high resistance to therapies, which necessitates the discovery of new biomarkers for
Simonovic, Sinisa
core +1 more source
Nature Communications, 2020 Sterol O-acyltransferase 1 (SOAT1, also named ACAT1) is an endoplasmic reticulum resident enzyme which catalyzes the esterification of cholesterol to generate cholesteryl esters.
Chengcheng Guan +9 more
doaj +1 more source
ABCD1 Transporter Deficiency Results in Altered Cholesterol Homeostasis
Biomolecules, 2023 X-linked adrenoleukodystrophy (X-ALD), the most common peroxisomal disorder, is caused by mutations in the peroxisomal transporter ABCD1, resulting in the accumulation of very long-chain fatty acids (VLCFA).
Agnieszka Buda +9 more
doaj +1 more source