Results 71 to 80 of about 2,949 (185)

Molecular actions of hypocholesterolaemic compounds from edible mushrooms [PDF]

, 2018
Cholesterol levels are strictly regulated to maintain its homeostasis; therefore, if it is not absorbed with the diet, the cholesterol biosynthetic pathway is enhanced and vice versa.
Gil-Ramírez, Alicia, Morales, Diego, Soler-Rivas, Cristina   +2 more
core   +1 more source

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Proteomic heterogeneity reveals SOAT1 as a potential biomarker for hepatocellular carcinoma

Translational Gastroenterology and Hepatology, 2019
Liver cancer is one of the few and fastest neoplastic malignancy to continue to rise in incidence in the United States and across the world (1). Today, the 5-year survival rate of liver cancer is approximately 17%, making it the 2nd most common cause of death from cancer worldwide (2).
Subreen A, Khatib, Xin Wei, Wang
openaire   +2 more sources

Stopping SOAT1 sparks an immune attack on liver cancer: a metabolic-immune axis in hepatocellular carcinoma

Oncologie
Ma et al. identified sterol O-acyltransferase 1 (SOAT1) as a key metabolic-immune node in hepatocellular carcinoma (HCC). These authors revealed that SOAT1 loss induced ROS-driven ER stress that activates IKKβ-NF-κB signaling and up-regulates the ...
Lonardo Amedeo, Weiskirchen Ralf
doaj   +1 more source

Bayesian non-negative factor analysis for reconstructing transcription factor mediated regulatory networks [PDF]

, 2011
Background Transcriptional regulation by transcription factor (TF) controls the time and abundance of mRNA transcription. Due to the limitation of current proteomics technologies, large scale measurements of protein level activities of TFs is
Jia Meng, Jianqiu (Michelle) Zhang, Yidong Chen, Yufei Huang   +3 more
core   +2 more sources

An ACAT inhibitor suppresses SARS-CoV-2 replication and boosts antiviral T cell activity [PDF]

, 2023
The severity of disease following infection with SARS-CoV-2 is determined by viral replication kinetics and host immunity, with early T cell responses and/or suppression of viraemia driving a favourable outcome.
Bailey, Dalan, Brown, Rachel, Davidson, Andrew D, Erdmann, Maximilian, Hansen, Scott B, Hinks, Timothy SC, Maini, Mala K, McKeating, Jane A, Morgan, Sophie B, Newman, Joseph, Peters, Rory, Schmidt, Nathalie M, Shionoya, Kaho, Swadling, Leo, Thakur, Nazia, Wang, Hao, Watashi, Koichi, Wing, Peter AC   +17 more
core   +2 more sources

RNA‐Binding Proteins and Ferroptosis in Cancer: Mechanism and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ferroptosis critically influences cancer cell fate and represents a promising therapeutic strategy. Emerging evidence identifies RNA‐binding proteins (RBPs) as key post‐transcriptional regulators of ferroptosis. The figure summarizes ferroptosis‐related RBPs across cancers: blue RBPs act as tumor suppressors by promoting ferroptosis, whereas red RBPs ...
Linlin Chang, Bin Lu, Haotian Shang, Wanjing Ding, Chunhua Wei, Xiaotian Qi, Pengxing He   +6 more
wiley   +1 more source

Combining Genome Wide Association Studies and Differential Gene Expression Data Analyses Identifies Candidate Genes Affecting Mastitis Caused by Two Different Pathogens in the Dairy Cow [PDF]

, 2015
Mastitis is a costly disease which hampers the dairy industry. Inflammation of the mammary gland is commonly caused by bacterial infection, mainly Escherichia coli, Streptococcus uberis and Staphylococcus aureus.
Chen, X, Cheng, Z R, Wathes, D C, Werling, D, Zhang, S   +4 more
core   +3 more sources

Proteomic Analysis of Regulated Dendritic Cell Endosomes Reveals Dynamic Adaptation to Antigen Uptake and Cross‐Presentation

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Phagocytosis of yeast activates recruitment of proteases and trafficking factors from the secretory and endosomal pathways to the IRAP compartment and subsequently phagosomes, promoting cross‐presentation. In the absence of Sec22b, IRAP endosome and phagosome maturation to late endosomes is accelerated.
Alice Senni, Louise Grumbach, Sara Ceccacci, Mathieu Frechin, Nicolas Goudin, Ida Chiara Guerrera, Barbara Bertocci, Peter van Endert   +7 more
wiley   +1 more source

Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage

Biomedicines, 2022
Glioblastoma (GBM) is the most lethal primary brain tumor. With limited therapeutic options, novel therapies are desperately needed. Recent studies have shown that GBM acquires large amounts of lipids for rapid growth through activation of sterol ...
Yongjun Kou, Feng Geng, Deliang Guo
doaj   +1 more source