Results 81 to 90 of about 2,949 (185)
Molecular targets of hypolipidemic action of sesquiterpene lactones [PDF]
, 2018 Experiments on rats with hyperlipidemia model induced by cholesterol-rich diet during 4 weeks showed that the daily treatment with sesquiterpene lactone grossgemin and ludartin in doses 10 mg/kg for a period of 14 days led to decrease ...
Кайдаш, О. А. +1 more
core
Estrogen receptor-dependent attenuation of hypoxia-induced changes in the lung genome of pulmonary hypertension rats [PDF]
, 2017 17β-estradiol (E2) exerts complex and context-dependent effects in pulmonary hypertension. In hypoxia-induced pulmonary hypertension (HPH), E2 attenuates lung vascular remodeling through estrogen receptor (ER)-dependent effects; however, ER target genes ...
Albrecht, Marjorie E. +3 more
core +1 more source
The Immune Microenvironment in Liver Cancer: From Analysis to Targeting
Advanced Science, Volume 12, Issue 47, December 18, 2025.This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan +5 more
wiley +1 more source
Journal of Lipid Research, 2009 To evaluate the effect of genetic background on high-density lipoprotein cholesterol (HDL) levels in Soat1−/− mice, we backcrossed sterol O-acyltransferase 1 (Soat1)−/− mice, originally reported to have elevated HDL levels, to C57BL/6 mice and ...
Zhiguang Su +6 more
doaj +1 more source
The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis [PDF]
, 2018 The eukaryotic endoplasmic reticulum (ER) membrane contains essential complexes that oversee protein biogenesis and lipid metabolism, impacting nearly all aspects of cell physiology.
Christianson, John +7 more
core +2 more sources
Cancer Stem Cells in Human Gastrointestinal and Hepatic Cancers
MedComm, Volume 6, Issue 12, December 2025.Gastrointestinal cancer stem cells obtain the ability of unlimited self‐renewal, drug resistance, tumorigenicity as well as tendency of metastasis. ABSTRACT Gastrointestinal cancers, including gastric, hepatic, and colorectal cancers, represent a major public health problem globally. Although the 5‐year survival rate of gastrointestinal tumors has been
Jiawen Bu +6 more
wiley +1 more source
A high through-put reverse genetic screen identifies two genes involved in remote memory in mice. [PDF]
PLoS ONE, 2008 Previous studies have revealed that the initial stages of memory formation require several genes involved in synaptic, transcriptional and translational mechanisms.
Anna Matynia +5 more
doaj +1 more source
Differential effect of mild and severe pulmonary embolism on the rat lung transcriptome [PDF]
, 2016 BACKGROUND: Pulmonary thromboembolism (PTE) is a common diagnosis and a leading cause of cardiovascular morbidity and mortality. A growing literature has associated PE with systemic inflammation, and global hyper-coagulability, which contribute to lung ...
Kline, Jeffrey A., Zagorski, John
core +2 more sources
Zhongguo linchuang yanjiu"Objective To investigate the mRNA expression levels of sterol O⁃acyltransferase 1（SOAT1）and triggering receptor expressed on myeloid cells 1（TREM1）in esophageal squamous cell carcinoma（ESCC）tissues and analyze their associations with clinical ...
LU Yang，GAO Chao
doaj +1 more source
Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature [PDF]
, 2014 BACKGROUND: Aging is accompanied by increasing vulnerability to pathologies such as atherosclerosis (ATH) and Alzheimer disease (AD). Are these different pathologies, or different presentations with a similar underlying pathoetiology?
Alexandra Sapronova +2 more
core +1 more source