Results 51 to 60 of about 7,401,341 (346)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Tired Socially – Now and Forever? Review of the Book by Byung-Chol Khan "The Society of Fatigue. Negative Experience in the Era of Excessive Positivity". Moscow: AST Publishing House, 2023. 161 p.

open access: yesСоциальная психология и общество
The reviewed book presents a philosophical view on a number of social and socio-psychological problems of the modern era, a significant part of which is analyzed through the prism of subjective human experiences, including destructive ones ...
E.P. Belinskaya
doaj   +1 more source

From crisis to comfort : contemporary bestsellers and the French Middlebrow’s narrative of recovery

open access: yesBelphégor, 2017
The present article proposes an account of the contemporary French Middlebrow through the study of a corpus of bestselling novels. I identify a recurring motif in the bestsellers of the Sarkozy years (2007-2012), a political period marked by debates on ...
Annamma Varghese
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

What does Marx mean by the "fetishism of commodities" ? [PDF]

open access: yes, 2010
The present paper aims to analyse Marx’s concept of “fetishism of commodities” by explaining the mechanism of a social genesis of determined illusions, arising in the sphere of production and circulation of commodities.
Dobra, Alexandra
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

La experiencia de la pobreza y su impacto en la organización popular de la ciudad de Lima

open access: yesAmérica Latina Hoy, 2009
RESUMEN: Con base en una investigación empírica realizada con técnicas cualitativas, se analiza la formación de organizaciones y acción colectiva en distintos tipos de estratos sociales en la ciudad de Lima.
María Ángeles LÓPEZ JIMÉNEZ
doaj   +3 more sources

[Review of the Book \u3ci\u3eAdvancing Theory in Labour Law and Industrial Relations in a Global Context\u3c/i\u3e] [PDF]

open access: yes, 1998
[Excerpt] The ideas and insights in Advancing Theory are an important contribution to the on-the-ground social justice movement challenging corporate rule in the global economy.
Compa, Lance A
core   +1 more source

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