Results 61 to 70 of about 7,401,341 (346)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Beyond Hyper-capitalism: can the sharing economy reshape sustainable development? [PDF]

, 2017
In nowadays globalized world, highly interconnected by various kind of networks, first of all the social networks, a radical phenomenon is rapidly gaining momentum: that of the sharing economy. From the United States to the Eastern Europe, the phenomenon
Gurashi, Romina
core  

The Characteristic of Postmodernism - Fragmentation and its Impact on the Process of English Language Learning: A Case Study [PDF]

, 2018
The teaching of a second language, especially English, seems to be on the raise given the importance of today´s globalized world. This article, an empirical study, was carried out through a survey with close-ended questions and text development, applied ...
Fuentealba, A. (Andrea), Galleguillos, J. (Juan), Muñoz, B. R. (Bruno), Philominraj, A. (Andrew)   +3 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Resilience and vulnerability of Ukrainians: The role of family during the war [PDF]

Problems and Perspectives in Management
The full-scale russian invasion of Ukraine led to numerous physical and moral challenges. The paper aims to estimate the role of family as a social resilience driver in managing wartime challenges on a regional level.
Andriana Kostenko, Volodymyr Semenov, Oksana Osetrova, Oleksandr Kubatko, Mykola Nazarov, Vitalii Stepanov   +5 more
doaj   +1 more source

Design and development of auxiliary components for a new two-stroke, stratified-charge, lean-burn gasoline engine [PDF]

, 2005
A unique stepped-piston engine was developed by a group of research engineers at Universiti Teknologi Malaysia (UTM), from 2003 to 2005. The development work undertaken by them engulfs design, prototyping and evaluation over a predetermined period of ...
Abdul Aziz, Azhar, Abdul Latif, Zulkarnain, Abu Bakar, Rosli, Mohd. Noor, Alias, Mohd. Rohani, Jafri, Saat, Aminuddin   +5 more
core  

Algorithms, Automation, and News [PDF]

This special issue examines the growing importance of algorithms and automation in the gathering, composition, and distribution of news. It connects a long line of research on journalism and computation with scholarly and professional terrain yet to be ...
Anderson C. W., Bruns Axel., Diakopoulos Nicholas., Gillespie Tarleton., Lewis Seth C., Pariser Eli., Schudson Michael., Sunstein Cass R., Sunstein Cass R.   +8 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source