Results 71 to 80 of about 7,401,341 (346)

NETWORK CHARACTER OF INTERNATIONAL TERRORISM AND THE POSSIBILITY OF THE CONSOLIDATION OF THE RUSSIAN SOCIETY

Vestnik RUDN. International Relations, 2017
The purpose of this article is to analyze the network of the mechanism of reproduction of international terrorism - the phenomenon of post-truth, strongly modifies the previous interpretation of the political, ethnic, religious, cultural and social ...
А В Абрамов, С Н Федорченко, К П Курылев   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Role of the Value Basis in the Context of Waging Non-Kinetic Wars: Methodological Prerequisites for Analysis

RUDN Journal of Political Science
The relevance of the topic presented in the article is determined primarily by the current foreign policy situation, namely the hybrid war unleashed by the collective West against the Russian Federation, a significant component of which are the so-called
Alexander V. Kurochkin
doaj   +1 more source

Understanding Productivity Levels, Dispersion and Growth in the Leather Shoe Industry: Effects of Size and Informality [PDF]

In this case study performed on the industrial sub-sector of manufacture of leather shoes in Bolivia, we use the Hsieh and Klenow model (2008) to determine the differences between productivity of larger and formal companies and productivity of smaller ...
Carlos Gustavo Machicado, Juan Cristóbal Birbuet   +1 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Global Trend of Individualization as a Factor of Social Transformation

Intercultural Communication, 2019
Vol. 1(6), 2019 l 141 ABSTRACT The article is dedicated to individualization, which is considered as a globalization trend that affects all spheres of life of modern person, causing the transformation of social relations and social character.
Kateryna Nastoiashcha
semanticscholar   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

General aviation piston-engine exhaust emission reduction [PDF]

, 1977
To support the promulgation of aircraft regulations, two airports were examined, Van Nuys and Tamiami. It was determined that the carbon monoxide (CO) emissions from piston-engine aircraft have a significant influence on the CO levels in the ambient air ...
Duke, L. C., Houtman, W. H., Kempke, E. E., Jr., Rezy, B. J., Westfield, W. T.   +4 more
core   +1 more source

Social Imagination and Solidarity in Precarious Times: The Case of Lower Class People in Post-Soviet Russia

, 2017
The paper seeks to enrich existing literature on group making by studying the process of group formation among lower class people in post-soviet Russia, which provides important findings on the way precarization and atomization in global neoliberal ...
K. Clément
semanticscholar   +1 more source