Results 121 to 130 of about 5,668,569 (360)

Lifetime History of Suicide Attempts among Not Guilty by Reason of Insanity State Hospital Inpatients: The Roles of past Harmful Substance Use and Current Social Support

, 2020
Sean M. Mitchell, Sarah L. Brown, Faith Scanlon, Marc T. Swogger, Darci Delgado, Maria I. Ventura, Angelea D. Bolaños, Robert D. Morgan   +7 more
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Wujud Nasionalisme Tokoh Modernis Islam: Kontribusi K.H. Mas Mansur dalam Mengantarkan Indonesia Merdeka

Jurnal Sejarah Citra Lekha
This study aims to reaffirm the role of K.H. Mas Mansur in the context of Indonesia's struggle for independence from colonial rule. The research employs historical research procedures, including heuristics (source gathering), verification (criticism of ...
Miftahuddin Miftahuddin, Danar Widiyanta, Adnan Rafsanjani   +2 more
doaj   +1 more source

Peer Review #1 of "Life history stage explains behavior in a social network before and during the early breeding season in a cooperatively breeding bird (v0.1)"

, 2020
Damien R. Farine
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Soft law for unintentional empathy: addressing the governance gap in emotion-recognition AI technologies

Journal of Responsible Technology
Despite regulatory efforts, there is a significant governance gap in managing emotion recognition AI technologies and those that emulate empathy. This paper asks: should international soft law mechanisms, such as ethical standards, complement hard law in
Andrew McStay, Vian Bakir
doaj   +1 more source

Taking History to Heart: the Power of the Past in Building Social Movements [PDF]

, 2002

openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

The Revolution of 1917 — the 1920s and the History of Social and Political Thought from Ivan Lysiak-Rudnytsky’s Perspective [PDF]

, 2017
Prominent Ukrainian historian Ivan Lysiak-Rudnytsky (1919–1984) repeatedly addressed the topic of the Ukrainian revolution of 1917 – the 1920s, especially considering its intellectual origins and implications in the context of the history of Ukrainian ...
Yosypenko, Serhii
core  

Conceptual History, Cultural History, Social History

ВИВЛIОθИКА: E-Journal of Eighteenth-Century Russian Studies, 2014
V. M. Zhivov’s introduction to Studies in Historical Semantics of the Russian Language in the Early Modern Period (2009), translated here for the first time, offers a critical survey of the historiography on Begriffsgeschichte, the German school of conceptual history associated with the work of Reinhart Koselleck, as well as of its application to the ...
openaire   +4 more sources