Results 151 to 160 of about 5,668,569 (360)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Adolescent identity: The importance of the social history. [PDF]
SAGE Open Med Case Rep, 2020 Silverstein L, Zander E, Middleman AB.
europepmc +1 more source
تاریخ اسلام, 2011 Social history is considered as one of the majors of history investigating a broad area relevant to the various aspects of human's life and culture as well as the structure, the procedure and the consequence of human's deed. This branch of historical studies has studied the history of inferiors and their social roles after too much attention to the ...
openaire +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Work history and the access to contributory pensions. The case of Uruguay. [PDF]
Incomplete and highly fragmented work histories threaten to leave many contributors of the pension schemes in Latin America without the minimum pension guarantee or even without access to the ordinary pension. We propose a methodology to assess this risk,
Alvaro Forteza +2 more
core
Advanced Ancient Steelmaking Across the Arctic European Landscape
Open ArchaeologyThis article presents results that seriously challenge conventional frameworks regarding the time, course, and cultural context of the introduction of iron and steel in Europe, in turn central metals in the narrative of civilization development.
Bennerhag Carina, Söderholm Kristina
doaj +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
CORPORATE SOCIAL RESPONSIBILITY IN ENGLISH FOOTBALL: HISTORY AND PRESENT [PDF]
The purpose of this descriptive research is to present what kind of corporate social responsibility (CSR) activities English football clubs are implementing.
Vlad ROŞCA
core
The Old Northwest Under British Control, 1763-1783 and Indiana A Part of the Old Northwest, 1783-1800 [PDF]
, 1987 This handbook was developed to encourage more effective state citizenship through the teaching of state history. Attention is given to geographical factors, politics, government, social and economic changes, and cultural ...
Geib, George W.
core +1 more source