Results 111 to 120 of about 2,905,334 (379)
Information technologies and gambling: a Durkheimian perspective [PDF]
, 2014 Gambling has a long history as a social practice, through which bonds can be created and maintained, and as a part of creative and reenacted social habits and celebrations.
Mundy-McPherson, S
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Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Proceedings of the Royal Society B: Biological Sciences, 2016 Eduardo Moreno +4 more
semanticscholar +1 more source
Changes in the use of time and the state of health of the Russian population in the 1980s-1990s [PDF]
This is an attempt to answer a question about how changes in the time use and in health the population relate to each other, what connection exists between duration and character of work and the state of health.
Olga Novokhatskaya, Viktor Artemov
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TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
Northrop Frye in context [PDF]
, 2012 “Diane Dubois takes a contextual approach to Northrop Frye’s work and claims that it is best assessed in relation to his biographical circumstances. In context and in specific details, Dubois’ book seeks to illuminate Frye’s œuvre as a personal, lifelong
Dubois, Diane, Hudson, John
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Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
From computing clerks to androids: two bits on the material lives of social data in India [PDF]
, 2016 The social and material conditions of data collection have a significant bearing on how we think about and understand data. Sandeep Mertia looks at the history of data collection in India and how the conditions have changed over time.
Mertia, Sandeep
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source