Results 91 to 100 of about 2,577,538 (366)

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Rethinking identity theory in light of the in-Christ identity in the African context

HTS Teologiese Studies/Theological Studies
In social identity theory, the in-Christ identity is understood as primarily a socially directed process in which people categorise themselves relative to other groups. Intergroup behaviour would cause them to discriminate against the so-called ‘outgroup’
Philip La G. Du Toit
doaj   +1 more source

The Facebook Project - The Missing Box: The Racial Politics Behind the Facebook Interface [PDF]

, 2008
There is no race, ethnicity or nationality category available the default Facebook profile. This, combined with the fact that Facebook is a visually-driven website, suggests that Facebook serves to inadvertently or covertly perpetuate two racist or ...
Ginger, Jeff
core  

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Examining Identity Intersectionality: Thai Marriage Migrants in the Netherlands

International Review of Social Psychology, 2018
With a comparative design and a mixed-methods approach, this research with Thai female marriage migrants in the Netherlands offers a novel examination of the theory of identity intersectionality.
Anouk Manassen, Maykel Verkuyten
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Rogue Athlete Endorsers: Using Social Identity Theory to Assess Brand Fit [PDF]

, 2012
Athlete endorsement deals typically assume that the brand will benefit from an association with the celebrity athlete\u27s public persona. When athletes find themselves in trouble with the law, spouses or frustrated fans, brands like Nike, Reebok, Buick,
Brinker, David L., Jr., Pokrywczynski, Jim   +1 more
core   +1 more source

Between a rock and a hard place: corporate elites in the context of religion and secularism in Turkey [PDF]

, 2014
Drawing on discourse analyses of 36 in-depth interviews with elite business people from Turkey, the study identifies the networking patterns of new and established business elites in the context of economic liberalization and socioreligious ...
Ali Ergur, Artun Ünsal, Biggart N. W., Bourdieu P., Buğra A., Mustafa Özbilgin, Pamuk Ş., Selcuk Uygur, Sibel Yamak, Özcan G. B.   +9 more
core   +2 more sources

Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients

Molecular Oncology, EarlyView.
Cancer‐associated fibroblasts (CAFs) promote cancer growth, invasion (metastasis), and drug resistance. Here, we identified functional and diverse circulating CAFs (cCAFs) in patients with metastatic prostate cancer (mPCa). cCAFs were found in higher numbers and were functional and diverse in mPCa patients versus healthy individuals, suggesting their ...
Richell Booijink, Leon W. M. M. Terstappen, Eshwari Dathathri, Khrystany Isebia, Jaco Kraan, John Martens, Ruchi Bansal   +6 more
wiley   +1 more source