Results 71 to 80 of about 8,448,369 (354)

Social isolation and its impact on child and adolescent development: a systematic review

Revista Paulista de Pediatria, 2021
Objective: This study aims to analyze the effects of social isolation on children's and teenagers’ development, with emphasis on the possible impacts over their physical and mental health.
Isabelle Lina de Laia Almeida, Jaqueline Ferraz Rego, Amanda Carvalho Girardi Teixeira, M. R. Moreira   +3 more
semanticscholar   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Modulation of social valence by insular cortex activity during acute social isolation in mice

Molecular Brain
For social animals, social isolation is a potential threat to survival, and therefore can be considered innately aversive. Long-term social isolation induces a variety of social and affective deficits and has been used as a stress model in animal studies,
Kanae Hiyoshi, Daichi Matsushita, Ayako M. Watabe   +2 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The associations of social isolation with depression and anxiety among adults aged 65 years and older in Ningbo, China

Scientific Reports
Social isolation was associated with emotional problems (depression and anxiety) among older adults, however, little is known in China. Thus, we conducted a cross-sectional study including 6,664 ≥ 65 years older adults in Ningbo, China. We collected data
Lian Li, Kaijie Pan, Jincheng Li, Meiqin Jiang, Yan Gao, Hongying Yang, Guolin Bian   +6 more
doaj   +1 more source

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

The experience of social isolation among community-dwelling older adults: a qualitative study

BMC Geriatrics
Background Social isolation is a major problem for older adults. Increasing evidence suggests that perceived social isolation is linked to adverse physical and mental health outcomes among older adults.
Mengfan He, Shitong Guo, Xiang Sun, Yi Yu, Ling Li, Jinhua Zhang, Shiguang Wang, Shuya Li, Peng Wang, Lin Zhang   +9 more
doaj   +1 more source

The role of social isolation in opioid addiction [PDF]

, 2021
Nina C. Christie
openalex   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

FEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii, Edoardo Andrea Cutolo, Daniele Montepietra, Claudia Battarra, Roberto Caferri, Stefano Capaldi, Zeno Guardini, Luca Dall'Osto, Roberto Bassi   +8 more
wiley   +1 more source

Recovery from social isolation requires dopamine in males, but not the autism-related gene nlg3 in either sex

Royal Society Open Science
Social isolation causes profound changes in social behaviour in a variety of species. However, the genetic and molecular mechanisms modulating behavioural responses to social isolation and social recovery remain to be elucidated.
Ryley T. Yost, Andrew M. Scott, Judy M. Kurbaj, Brendan Walshe-Roussel, Reuven Dukas, Anne F. Simon   +5 more
doaj   +1 more source