Results 71 to 80 of about 1,514,946 (349)

Loneliness and social isolation How can we protect our mental health and cognitive functions? [PDF]

, 2023
Jing Liang, S Watanabe, S Watanabe, A Shao, S Watanabe, J Liang   +5 more
openalex   +1 more source

Eliminating Social Homelessness: Providing a Home to Grow [PDF]

, 2016
Middle school students who belong to marginalized identity groups often experience alienation and isolation. These feelings are compounded for multi-marginalized students who experience social homelessness–a term Harrison (2015) uses to describe students
Akos, Patrick, Duquette, Kevin, Harrison, Rydell   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Neighborhood social cohesion and physical disorder in relation to social isolation in older adults: racial and ethnic differences

BMC Public Health
Background Neighborhood factors of social isolation have been understudied, hindering efforts to reduce social isolation at the neighborhood level. This study aims to investigate the longitudinal effects of neighborhood social cohesion and physical ...
Weidi Qin, Emily J. Nicklett, Jiao Yu, Ann W. Nguyen   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

GAMBARAN KEMAMPUAN INTERAKSI SOSIAL PASIEN ISOLASI SOSIAL SETELAH PEMBERIAN SOCIAL SKILLS THERAPY DI RUMAH SAKIT JIWA

Jurnal Ilmiah Kesehatan, 2018
Social isolation is one of the nursing diagnoses that can be established in patients who are symptomatic to withdraw, withdraw from social activities and do not want to interact with others even with nurses.
Sukma Ayu Candra Kirana
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Association Between Ego-Resilience and Social Isolation Among Urban Older People

Gerontology and Geriatric Medicine
Social isolation among older adults affects their physical and mental health. Ego-resilience is associated with flexible adaptation to various environments and acceptable behaviors.
Kazuaki Hashimoto MD, PhD, Takeaki Takeuchi MD, PhD, Kazushige Ihara MD, PhD, Shuichi Obuchi PT, PhD, Hisashi Kawai PhD, Hirohiko Hirano DDS, PhD, Yoshinori Fujiwara MD, PhD, Kim Hunkyung PhD, Yutaka Watanabe DDS, PhD, Masahiro Hashizume MD, PhD   +9 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The association of social isolation and loneliness with sarcopenia among the middle-aged and elderly in China

BMC Psychiatry
Objectives This study examined the relationship of social isolation and loneliness on sarcopenia among Chinese middle-aged and elderly people. Methods Social isolation, loneliness, and sarcopenia were measured at baseline. Follow-up measures of new-onset
Lei Tu, Yiqun Li, Xiao Ren, Minglan Jiang, Longyang Han, Xiaowei Zheng   +5 more
doaj   +1 more source