Results 101 to 110 of about 237,174 (301)

PENGARUH LONELINESS DAN SELF-CONTROL TERHADAP INSTAGRAM SOCIAL MEDIA DISORDER PADA EMERGING ADULTHOOD [PDF]

Inappropriate use of Instagram social media and the habit of accessing it excessively can have bad effects, one of which is addiction, mental health disorders (loneliness), and disturbances in self-control, which are categorized as social media disorder.
Nuwada, Tiara Putri
core  

Problem gambling: a suitable case for social work? [PDF]

, 2013
Problem gambling attracts little attention from health and social care agencies in the UK. Prevalence surveys suggest that 0.6% of the population are problem gamblers and it is suggested that for each of these individuals, 10–17 other people ...
Alexander B., Bellringer P., Bickley P., Brenner R., Chinn C., Cree V., Crisp B., Daddow R., Derevensky J., Flavin M., Gambling Commission, Gaudia R., Golightley M., Goodman R., Gould N., Griffiths M. D., Griffiths M. D., Griffiths M. D., Griffiths M. D., Jim Rogers, Layard R., May Chahal C., Nielsen Media Research, Orford J., Orford J., O’Keeffe M., Petry N., Productivity Commission, Reith G., Reith G., Reith G., Responsible Gambling Strategy Board, Rigbye J., Rowntree B., Shaffer H. J., Sullivan S., Tew J., Victorian Casino and Gambling Authority (VCGA), Volberg R., Walker M., Wardle H., Wright Mills C., Zarin D. A.   +42 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Roots Reloaded. Culture, Identity and Social Development in the Digital Age [PDF]

, 2016
This edited volume is designed to explore different perspectives of culture, identity and social development using the impact of the digital age as a common thread, aiming at interdisciplinary audiences.
Gansinger, Martin A. M., Kole, Ayman
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

The mediating effect of social network identity management on the relationship between personality traits and social media addiction among pre-service teachers

BMC Psychology
Background The use of social media has become an important part individuals’ daily lives and is used in many daily life activities, such as social interaction, education, and shopping.
Onur Isbulan, Emre Cam, Mark D. Griffiths   +2 more
doaj   +1 more source

The Relationship Between Social Media Addiction and Self-Esteem in Medical Students of Diponegoro University

Jurnal Kedokteran Diponegoro
Background: In the modern era, social media has become a necessity in carrying out daily activities. Playing social media too often can have negative effects. These negative effects include addiction.
Difa Maulana Subiyakto, Fanti Saktini, Tanjung Ayu Sumekar   +2 more
doaj   +1 more source