Results 71 to 80 of about 663,468 (311)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Technological cooperation network in biotechnology: Analysis of patents with Brazil as the priority country [PDF]

Innovation & Management Review, 2018
Purpose - The establishment of partnerships between companies, government and universities aims to enhance innovation and the technological development of institutions.
Cristiano Gonçalves Pereira, Rodrigo Ribeiro da Silva, João Ricardo Lavoie, Geciane Silveira Porto   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Computational prediction of new therapeutic effects of probiotics

Scientific Reports
Probiotics are living microorganisms that provide health benefits to their hosts, potentially aiding in the treatment or prevention of various diseases, including diarrhea, irritable bowel syndrome, ulcerative colitis, and Crohn’s disease.
Sadegh Sulaimany, Kajal Farahmandi, Aso Mafakheri   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Social Network Analysis of Occupational Segregation [PDF]

SSRN Electronic Journal, 2008
We propose an equilibrium interaction model of occupational segregation and labor market inequality between two social groups, generated exclusively through the documented tendency to refer informal job seekers of identical "social color". The expected social color homophily in job referrals strategically induces distinct career choices for individuals
I. Sebastian Buhai, Marco J. van der Leij   +1 more
openaire   +12 more sources

How Do Educational Researchers Organize Their Work? A Social Network Analysis on Co-authorship Relations

, 2017
Social network analysis brings new perspectives to the study of social phenomena. Traditional sociological analysis is usually focused on the categorization of data.
Viseu, Sofia
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

The Push and Pull of Network Mobility: How Those High in Trait-Level Neuroticism Can Come to Occupy Peripheral Network Positions

Behavioral Sciences, 2019
Field research shows that people’s network positions are determined, at least in part, by their traits. For instance, over time, actors higher in trait-level neuroticism move out to the network periphery.
Eric Gladstone, Kathleen M. O’Connor, Wyatt Taylor   +2 more
doaj   +1 more source

Social Network Analysis: Applications: Event Programme

, 2007
This seminar explores a number of current uses and applications of network analysis, including applications in social movement analysis, criminology, socio-linguistics and the study of literary networks.
Social Network, Analysis
core