Results 81 to 90 of about 6,308,164 (355)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

What do we need to add to a social network to get a society? answer: something like what we have to add to a spatial network to get a city [PDF]

open access: yes, 2009
Recent years have seen great advances in social network analysis. Yet, with a few exceptions, the field of network analysis remains remote from social theory.
Hillier, B.
core  

Missing data in multiplex networks: a preliminary study

open access: yes, 2014
A basic problem in the analysis of social networks is missing data. When a network model does not accurately capture all the actors or relationships in the social system under study, measures computed on the network and ultimately the final outcomes of ...
Magnani, Matteo   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Constructing, conducting and interpreting animal social network analysis

open access: yesJournal of Animal Ecology, 2015
Summary Animal social networks are descriptions of social structure which, aside from their intrinsic interest for understanding sociality, can have significant bearing across many fields of biology.
D. Farine, H. Whitehead
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An Introduction to Community Detection in Multi-layered Social Network

open access: yes, 2012
Social communities extraction and their dynamics are one of the most important problems in today's social network analysis. During last few years, many researchers have proposed their own methods for group discovery in social networks.
F. Radicchi   +6 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The Push and Pull of Network Mobility: How Those High in Trait-Level Neuroticism Can Come to Occupy Peripheral Network Positions

open access: yesBehavioral Sciences, 2019
Field research shows that people’s network positions are determined, at least in part, by their traits. For instance, over time, actors higher in trait-level neuroticism move out to the network periphery.
Eric Gladstone   +2 more
doaj   +1 more source

Towards an online design studio: a study of social networking in design distance learning [PDF]

open access: yes, 2009
In this paper we examine the role of social networking and online community building in distance design learning. We analysed interactions of Facebook, a popular social network site, using qualitative content analysis and social network analysis.
Schadewitz, Nicole   +1 more
core  

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