Results 91 to 100 of about 34,702,432 (300)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Social Network Analysis with sna [PDF]
Modern social network analysis---the analysis of relational data arising from social systems---is a computationally intensive area of research. Here, we provide an overview of a software package which provides support for a range of network analytic ...
Carter T. Butts
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Social positions and simulation relations
, 2011 Describing social positions and roles is an important topic within the social network analysis. Identifying social positions can be difficult when the target organization lacks a formal structure or is partially hidden.
Brynielsson, Joel, +5 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Social network analysis for judgment aggregation
International Joint Conference on Autonomous Agents and Multiagent Systems, 2014 The majority of work in judgment aggregation is devoted to the study of impossibility results. However the (social) dependencies that may exist between the voters has received less attention. In this extended abstract we use the degree centrality measure from social network analysis and obtain a correspondence between the average voter rule and this ...
Silvano Colombo Tosatto, Marc van Zee
openaire +3 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Networks in the analysis of decision-making processes
, 2009 Applicazione della network analysis nello studio dei processi ...
PISELLI, FORTUNATA
core
ConnectionsThe COVID-19 pandemic resulted in multiple UK-wide lockdowns, which prevented individuals from meeting friends and family outside their confined households.
Shepherd Ryan J. +2 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source