Results 141 to 150 of about 654,954 (312)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

PENERAPAN METODE COURSE REVIEW HORAY DALAM UPAYA MENINGKATKAN MINAT DAN HASIL BELAJAR ILMU PENGETAHUAN SOSIAL SISWA KELAS VIII F SMP N 2 NGEMPLAK

, 2017
Penelitian ini bertujuan untuk mengetahui: (1) upaya meningkatkan minat belajar danhasil belajar siswa pada pembelajaran IPS di kelas VIII F SMP N 2 Ngemplak menggunakan Metode Course Review Horay, (2) hasil peningkatan minat belajar dan hasil belajar ...
Putri, Avelina Oktaviani
core  

The Effect Of Thinking Education Course On The Success Of Social Studies Course

, 2019
In this research, it is investigated whether Thinking Education course, which is aimed at gaining the students thinking skills, will have a positive or negative effect on the success of Social Studies course in terms of skills. During the research, the change of students' perceptions of thinking education course was examined.
Tokmak, Ahmet, Şeker, Mustafa, Yılmaz, Ali   +2 more
openaire   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Social role patterning in early adulthood in the USA: adolescent predictors and concurrent wellbeing across four distinct configurations

, 2012
The decade following secondary school is pivotal in setting the stage for adulthood functioning and adjustment. We identify four social role configurations of early adults in their mid-20s using latent class analyses in two nationally representative ...
Schulenberg, John, Patrick, Megan E, Maggs, Jennifer L, Jager, Justin   +3 more
core   +1 more source

Life course studies – conceptual and methodological approaches and solution

Социологическая наука и социальная практика
Studies of the life course address the fundamental issue of social sciences – understanding the social change, its directions, reasons and perspectives, the interaction of micro- and macro levels of social reality.
Anna V. Andreenkova
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Life-course socioeconomic status and obesity: scoping review

Population Health Metrics
Objectif The life-course approach is believed to enhance our understanding of the intricate links between life-course socioeconomic status and obesity.
Habila Adamou, Marie-Claude Paquette, Dener François, Éric Robitaille, Sékou Samadoulougou Ouindpanga, Alexandre Lebel   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source