Results 121 to 130 of about 654,954 (312)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

A consensus statement on child and family health during the COVID-19 pandemic and recommendations for post-pandemic recovery and re-build

Frontiers in Child and Adolescent Psychiatry
IntroductionAs health systems struggled to respond to the catastrophic effects of SARS-CoV-2, infection prevention and control measures significantly impacted on the delivery of non-COVID children's and family health services.
Caroline A. B. Redhead, Sergio A. Silverio, Sergio A. Silverio, Elana Payne, Elana Payne, Mari Greenfield, Mari Greenfield, Sara M. Barnett, Anna Chiumento, Beth Holder, Helen Skirrow, Ofelia Torres, Carmen Power, Staci M. Weiss, Laura A. Magee, Soo Downe, Lucy Frith, Claire Cameron   +17 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Students’ Perspectives on Social Studies Teachers’ Views on Immigration and Nationalism

, 2021
This mixed-methods study examines students’ perspectives on their high school social studies teachers’ views and pedagogy surrounding the issues of immigration, nationalism, and patriotism within the classroom.
Jeffries, Hannah, McCorkle, William David   +1 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

From imputation to impact

, 2018
The topics included in this issue range from the imputation of missing data in longitudinal surveys to demonstrating that their results make a difference in the public arena – both challenges to our research field the world over.
Joshi, Heather
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Following people through time : an analysis of individual residential mobility biographies

, 2015
Maarten van Ham’s contribution to this research was partly made possible through the financial support of the EU Marie Curie programme under the European Union's Seventh Framework Programme (FP/2007-2013) / Career Integration Grant n.
Van Ham, Maarten, Coulter, Rory Christopher   +1 more
core   +1 more source

Exploring the Impact of the COVID-19 pandemic on depression in middle-aged and older Canadians with diabetes: Insights on incidence, recurrence, and risk factors from the Canadian longitudinal study on aging

Archives of Gerontology and Geriatrics Plus
Purpose: Individuals with diabetes have an elevated risk of depression. The occurrence of the COVID-19 pandemic may have further impacted the mental health of patients living with diabetes.
ZhiDi Deng, B.Sc, PharmD, Grace Li, PhD, Maria E. Rowsell, MSW, RSW, Dorina Cadar, Esme Fuller-Thomson, PhD   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source