Results 111 to 120 of about 7,948,477 (335)
Educational Academic ResearchRecent curriculum development efforts in Türkiye reveal that a paradigm centred on active participation, which places the student at the heart of the learning-teaching process in social studies education, is now dominant.
Ahmet Ulusoy
doaj +1 more source
Integrating Philosophy with Children into the Social Studies Courses
Sosyal Bilimler ve Eğitim Dergisi, 2023 Philosophy with children aims to teach children to think for themselves and make informed choices. The objective here is to develop children's reasoning skills by enabling them to reflect on thinking while discussing concepts that are important to them.
openaire +2 more sources
Life course building epidemiology: An alternative approach to the collection and analysis of carbon emission data [PDF]
, 2005 Developing policy for the reduction of the carbon emissions due to buildings requires models for energy usage that incorporate social, behavioural, and environmental factors in addition to the physical properties and technical specifications of the ...
Bruhns, HR +4 more
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
International Journal of Health Geographics, 2004 Background There is evidence of a contribution of early life socioeconomic exposures to the risk of chronic diseases in adulthood. However, extant studies investigating the impact of the neighborhood social environment on health tend to characterize only
Whitsel Eric A +7 more
doaj +1 more source
Closing the Loop: Creating Deliverables That Add Value [PDF]
, 2016 As special collections librarians and liaison librarians work together to create innovative experiences working with primary source material, it is important to remember students have much to offer in the collaborative design process. In this case study,
DeSanto, Daniel L., Doherty, Prudence J.
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
Journal of Clinical and Translational Science, 2018 IntroductionThe Best Practices in Social and Behavioral Research Course was developed to provide instruction on good clinical practice for social and behavioral trials.
Susan L. Murphy +12 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source