Results 101 to 110 of about 7,948,477 (335)

Social Studies Teacher Candidates’ Views about Course Books

Turkish Studies-Educational Sciences
Bu çalışmanın amacı, Sosyal Bilgiler öğretmen adaylarının ortaokulda okutulan Sosyal Bilgiler ders kitaplarına ilişkin metaforlarını eleştirel bir bakış açısıyla ortaya koymaktır. Araştırma, sosyal bilgiler öğretmen adaylarının öğretim araç ve gereçleri arasında yer alan ders kitaplarını nasıl yorumladıklarını ve “iyi bir ders ...
Ali ALTIKULAÇ, Osman SABANCI
openaire   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Well-Being Throughout the Senior Years: An Issues Paper on Key Events and Transitions in Later Life [PDF]

Social Development Canada’s mission is “to strengthen Canada’s social foundations by supporting the well-being of individuals, families and communities and their participation through citizen focused policies, programs and services” (Social Development ...
Karen Kusch, Margaret Denton
core   +3 more sources

Data Note: Social role transitions (further/higher education, employment, living situation, parenthood, and being a carer) in the G1s of the Avon Longitudinal Study of Parents and Children (ALSPAC) [version 1; peer review: 2 approved]

Wellcome Open Research
Background Social roles common to adulthood (e.g. employment, parenthood) and their timing and combinations have been shown to relate to health. However, there is a lack of contemporary data to study complex patterns.
Rebecca Lacey, Anne McMunn, Laura Howe, Annie Herbert, Jon Heron, Ingrid Schoon   +5 more
doaj   +1 more source

Interdisciplinary island studies: connecting the social sciences, natural sciences and humanities [PDF]

Island Studies Journal, 2016
In this paper, we present the outline of an interdisciplinary undergraduate course entitled: “Islands: Models for our Planet – Metaphors for our World”, and will reflect on insights gained during its development and teaching in two consecutive academic ...
Sietze J. Norder, Kenneth F. Rijsdijk
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Data Note: Social role transitions (further/higher education, employment, living situation, parenthood, and being a carer) in the G1s of the Avon Longitudinal Study of Parents and Children (ALSPAC) [version 2; peer review: 2 approved, 1 not approved]

Wellcome Open Research
Background Social roles common to adulthood (e.g. employment, parenthood) and their timing and combinations have been shown to relate to health. However, there is a lack of contemporary data to study complex patterns.
Rebecca Lacey, Anne McMunn, Laura Howe, Annie Herbert, Jon Heron, Ingrid Schoon   +5 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Consultation and consequences: A view on the services experienced by some young people and six families

, 2004
Reports the views of some young people and 6 families on services received from social care professionals. Summarises the main themes that emerged and emphasises the issue of professional reliability as articulated in these 2 small, but in depth, studies.
Joshi, M., Owen, R., Seden, J., Williams, C.   +3 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source