Results 51 to 60 of about 2,714,980 (262)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
HydrologyFreshwater, vital for life and ecosystems, accounts for only 2.5% of Earth’s water, and is primarily located in polar caps, underground reservoirs, and surface water.
Eduardo de Miguel-García +1 more
doaj +1 more source
Alkali activated fly ash binders. A comparative study between sodium and potassium activators
Materiales de Construccion, 2006 This paper shows the effect of the nature of some alkaline activators in the microstructural development of thermal-alkali activated f/y ash systems. The alkaline compounds employed in this investigation were: NaOH, KOH, Na2C03, K2C03, sodium silicate ...
A. Fernández-Jiménez +2 more
doaj +1 more source
Fenchone, a monoterpene: Toxicity and diuretic profiling in rats
Frontiers in Pharmacology, 2023 Fenchone is a monoterpene present in the essential oils of various plants, including Foeniculum vulgare and Peumus boldus. Previous studies confirmed the anti-inflammatory, antioxidant, wound-healing, antidiarrheal, antifungal, antinociceptive, and ...
Asifa Bashir +3 more
doaj +1 more source
Theoretical implication of liganding reactions in axonal sodium channel gating [PDF]
, 1980 Dorogi PL, Neumann E. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 1980;2:45-51.Mathematical simulation models for measured permeability properties of axonal Na+ channels point to the ...
Dorogi, Peter L., Neumann, Eberhard
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
The Toxic Effect of Lanthanum on Planaria Is Mediated by a Variety of Ion Channels
Toxics, 2018 The effect of toxic concentrations of La3+ on the Ca, K, Na, Mg, and Cl channels of planaria was investigated through the use of various agonists and antagonists to those channels.
Wayne Briner
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Journal of Education, Health and SportBackground: Sodium homeostasis disruption is a fundamental pathophysiological mechanism in kidney diseases that critically affects the progression of renal dysfunction and the development of cardiovascular complications.
Anatoliy Gozhenko +4 more
doaj +1 more source