Results 51 to 60 of about 2,029,470 (268)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Medical Journal of BabylonBackground: Chronic kidney disease (CKD) is a rapidly expanding public health problem typified by either an increased excretion of albumin in the urine, a reduced glomerular filtration rate, or both.
Rawaa G. Abdullah +2 more
doaj +1 more source
FoodsEfforts to reduce sodium chloride levels in meat products within the European Union are closely aligned with the World Health Organization’s recommendation to limit daily sodium intake to a maximum of 5 g per person.
Miroslav Jůzl +6 more
doaj +1 more source
LETM1-Mediated K+ and Na+ Homeostasis Regulates Mitochondrial Ca2+ Efflux
Frontiers in Physiology, 2017 Ca2+ transport across the inner membrane of mitochondria (IMM) is of major importance for their functions in bioenergetics, cell death and signaling. It is therefore tightly regulated.
Shane Austin +8 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Current Developments in NutritionBackground: Unhealthy dietary habits such as high-sodium intake, are socially embedded and often resistant to individual-level interventions. Family-led approaches, where 1 member initiates change within the household, may offer a more effective ...
Kimberly Mei Yi Low +4 more
doaj +1 more source
Salinity reduces nutrients absorption and efficiency of their utilization in cassava plants
Ciência Rural, 2018 : The objective of this research was to evaluate the influence of salinity on the absorption and utilization of nutrients by cassava. For the study, cassava was submitted to four saline concentrations: 0, 20, 40, and 60mM NaCl.
Jailson Lopes Cruz +3 more
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Indian Journal of AnaesthesiaBackground and Aims: Sepsis-associated acute kidney injury (SA-AKI) significantly contributes to morbidity and mortality. Current biomarkers have limitations, necessitating the exploration of alternative indicators.
Rajathadri Hosur Ravikumar +5 more
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source