Results 21 to 30 of about 9,216 (139)

High-throughput screening and chemotype-enrichment analysis of ToxCast phase II chemicals evaluated for human sodium-iodide symporter (NIS) inhibition

Environment International, 2019
In support of the Endocrine Disruptor Screening Program (EDSP), the U.S.EPA's Office of Research and Development (ORD) is developing high-throughput screening (HTS) approaches to identify chemicals that alter target sites in the thyroid hormone (TH ...
Jun Wang, Daniel R. Hallinger, Ashley S. Murr, Angela R. Buckalew, Ryan R. Lougee, Ann M. Richard, Susan C. Laws, Tammy E. Stoker   +7 more
doaj  

Sodium chloride promotes macrophage pyroptosis and aggravates rheumatoid arthritis by activating SGK1 through GABA receptors Slc6a12

International Journal on Biological Sciences
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by synovial inflammation and the production of autoantibodies. Previous studies have indicated an association between high-salt diets (HSD) and an increased risk of RA, yet ...
Xianzheng Zhang, Ziwei Zhang, Yuchen Zhao, Lin Jin, Yu Tai, Yujing Tang, Shuo Geng, Han Zhang, Yufang Zhai, Yining Yang, Pin Pan, Peng He, Shuqi Fang, Chenlong Sun, Yu Chen, Mengqi Zhou, Lianghu Liu, Han Wang, Li Xu, Tianjing Zhang, Jinghan Hua, Hua Wang, Lingling Zhang   +22 more
semanticscholar   +1 more source

Sodium-coupled glucose transport, the SLC5 family, and therapeutically relevant inhibitors: from molecular discovery to clinical application

Pflügers Archiv: European Journal of Physiology, 2020
Sodium glucose transporters (SGLTs) belong to the mammalian solute carrier family SLC5. This family includes 12 different members in human that mediate the transport of sugars, vitamins, amino acids, or smaller organic ions such as choline.
Gergely Gyimesi, Jonai Pujol-Giménez, Y. Kanai, M. Hediger   +3 more
semanticscholar   +1 more source

Differential changes in anatomical, molecular and functional determinants of intestinal glucose absorption during murine pregnancy

Physiological Reports, Volume 13, Issue 15, August 2025.
Abstract Pregnancy demands increased food intake and nutrient delivery to support the growing conceptus. The timing and regional specificity of adaptations in small intestinal (SI) anatomy and transport, and their functional consequences, remain unclear. We therefore assessed anatomy and expression of macronutrient transporters in the duodenum, jejunum,
T. Sebastian Overduin, Georgia S. Clarke, Hui Li, Richard L. Young, Kathryn L. Gatford, Amanda J. Page   +5 more
wiley   +1 more source

Molecular Dynamics Simulations of a Putative Novel Mechanism for UCP1‐Assisted FA Anion Transport

Acta Physiologica, Volume 241, Issue 7, July 2025.
ABSTRACT Background Mitochondrial energy can be stored as ATP or released as heat by uncoupling protein 1 (UCP1) during non‐shivering thermogenesis in brown adipose tissue. UCP1, located in the inner mitochondrial membrane, reduces the proton gradient in the presence of long‐chain fatty acids (FA).
Sanja Vojvodić, Giorgia Roticiani, Mario Vazdar, Elena E. Pohl   +3 more
wiley   +1 more source

Rare earth 4-hydroxycinnamate compounds as carbon dioxide corrosion inhibitors for steel in sodium chloride solution

, 2014
A series of rare earth 4-hydroxycinnamate compounds including Ce(4OHCin)3, La(4OHCin)3, and Pr(4OHCin)3 has been syn- thesized and evaluated as novel inhibitors for carbon dioxide corrosion of steel in CO2-saturated sodium chloride solutions ...
N. Nam, M. Mathesh, B. Hinton, M. Tan, M. Forsyth   +4 more
semanticscholar   +1 more source

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science, Volume 12, Issue 17, May 8, 2025.
This study uses Caenorhabditis elegans to assess the activity of amphetamine‐type stimulants (ATS) and their analogs. The research highlights the roles of dopamine and serotonin pathways, distinguishes chiral forms of ATS, and identifies structure‐activity relationships. These findings provide a rapid and cost‐effective model for evaluating the effects
Yuanpeng Li, Hongyuan Li, Hongshuang Wang, Xiaohui Wang   +3 more
wiley   +1 more source

Generation of Conformation‐Specific Monoclonal Antibodies for Integral Membrane Proteins

Current Protocols, Volume 5, Issue 5, May 2025.
Abstract Antibodies and their antigen‐binding fragments, including fragment antigen‐binding domains (Fabs) and single‐chain variable fragments (scFvs), are extraordinary tools in all fields of biology, particularly in neuroscience, where they have been utilized for imaging, detection, and quantification studies.
Natalie Sheldon, Gunasekaran Dhandapani, Junhoe Kim, Cathy J. Spangler, Chengli Fang, Jumi Park, Prashant Rao, Eric Gouaux   +7 more
wiley   +1 more source

Update of the Scientific Opinion on the risks for human health related to the presence of perchlorate in food

EFSA Journal, Volume 23, Issue 5, May 2025.
Abstract The European Commission asked EFSA to update its 2014 risk assessment on perchlorate in food. Perchlorate is a contaminant of both natural and anthropogenic sources present in food and drinking water. It is a substrate for the sodium iodide symporter (NIS) and competitively inhibits the uptake of iodide into the thyroid.
EFSA Panel on Contaminants in the Food Chain (CONTAM), Helle Katrine Knutsen, Agneta Åkesson, Vasileios Bampidis, Margherita Bignami, Laurent Bodin, Gisela Degen, Antonio Hernández‐Jerez, Tim Hofer, Christer Hogstrand, Stefano Landi, Jean‐Charles Leblanc, Kyriaki Machera, Evangelia Ntzani, Guido Rychen, Salomon Sand, Katharina Vejdovszky, Barbara Viviani, Aleksandra Buha Djordjevic, Thorhallur Halldorsson, Chantra Eskes, Olaf Mosbach‐Schulz, Francesca Riolo, Elena Rovesti, Efisio Solazzo, Alexios Zormpas, Tuuli Tauriainen, James Kevin Chipman   +27 more
wiley   +1 more source

Piezoelectric Biomaterial with Advanced Design for Tissue Infection Repair

Advanced Science, Volume 12, Issue 10, March 13, 2025.
This review offers a comprehensive overview of piezoelectric materials in antibacterial treatments, emphasizing the configuration of piezoelectric biomaterial, the mechanisms behind their antibacterial effects, and their current applications in tissue engineering.
Siyuan Shang, Fuyuan Zheng, Wen Tan, Zhengyi Xing, Siyu Chen, Fuli Peng, Xiang Lv, Duan Wang, Xiangdong Zhu, Jiagang Wu, Zongke Zhou, Xingdong Zhang, Xiao Yang   +12 more
wiley   +1 more source