Results 21 to 30 of about 14,950 (202)

Multisecond ligand dissociation dynamics from atomistic simulations [PDF]

Nat. Commun. 11, 2918 (2020), 2020
Coarse-graining of fully atomistic molecular dynamics simulations is a long-standing goal in order to allow the description of processes occurring on biologically relevant timescales. For example, the prediction of pathways, rates and rate-limiting steps in protein-ligand unbinding is crucial for modern drug discovery. To achieve the enhanced sampling,
arxiv   +1 more source

The Atypical Stimulant and Nootropic Modafinil Interacts with the Dopamine Transporter in a Different Manner than Classical Cocaine-Like Inhibitors [PDF]

, 2011
Modafinil is a mild psychostimulant with pro-cognitive and antidepressant effects. Unlike many conventional stimulants, modafinil has little appreciable potential for abuse, making it a promising therapeutic agent for cocaine addiction.
Reith, Maarten E. A., Schmitt, Kyle C.
core   +11 more sources

Chloride in Heart Failure:The Neglected Electrolyte [PDF]

, 2021
The increasing burden of heart failure (HF) and emerging knowledge regarding chloride as a prognostic marker in HF have increased the interest in the pathophysiology and interactions of chloride abnormalities with HF-related factors and treatments ...
Ezekowitz, Justin A., Julius, Florine E.C., McAlister, Finlay A., Pannu, Neesh, Sepehrvand, Nariman, van Norel, Margje R., Voors, Adriaan A., Zandijk, Arietje J.L.   +7 more
core   +1 more source

Distribution and dynamics of Tc-99m-pertechnetate uptake in the thyroid and other organs assessed by single-photon emission computed tomography in living mice [PDF]

, 2010
Background: Tc-99m pertechnetate is a well-known anion, used for clinical imaging of thyroid function. This gamma emitter is transported by the sodium iodide symporter but is not incorporated into thyroglobulin. Scintigraphy using Tc-99m pertechnetate or
Darcourt, Jacques, Defrise, Michel, Franken, Philippe R, Guglielmi, Julien, Koulibaly, Malick, Pourcher, Thierry, Vanhove, Christian   +6 more
core   +1 more source

Chemical inhibitors as potential allied for CO2 replacement in gas hydrates reservoirs: sodium chloride case study

Proceedings of the 6th World Congress on Mechanical, Chemical, and Material Engineering, 2020
In previous experimental works we proved how the presence of sodium chloride may influence the replacement of methane contained into hydrate with carbon dioxide.
A. Gambelli, B. Castellani, M. Filipponi, A. Nicolini, F. Rossi   +4 more
semanticscholar   +1 more source

Functional interplay between CFTR and pendrin: physiological and pathophysiological relevance [PDF]

, 2022
: The transport of chloride and bicarbonate across epithelia controls the pH and volume of the intracellular and luminal fluids, as well as the systemic pH and vascular volume.
Dossena, Silvia, Tamma, Grazia
core   +2 more sources

Sodium chloride inhibits effective bubbly drag reduction in turbulent bubbly Taylor–Couette flows [PDF]

Philosophical Transactions of the Royal Society A, 2022
Using the Taylor–Couette geometry we experimentally investigate the effect of salt on drag reduction caused by bubbles present in the flow. We combine torque measurements with optical high-speed imaging to relate the bubble size to the drag experienced ...
Luuk J. Blaauw, D. Lohse, S. Huisman
semanticscholar   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Transporters [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
Aldrich, R, Alexander, SPH, Attali, B, Back, M, Barnes, NM, Bathgate, R, Beart, PM, Becirovic, E, Benson, HE, Biel, M, Birdsall, NJ, Boison, D, Brauner-Osborne, H, Broeer, S, Bryant, C, Burnstock, G, Burris, T, Cain, D, Calo, G, Chan, SL, Chandy, KG, Chiang, N, Christakos, S, Christopoulos, A, Chun, JJ, Chung, J-J, Clapham, DE, Connor, MA, Coons, L, Cox, HM, Dautzenberg, FM, Davies, JA, Dent, G, Douglas, SD, Dubocovich, ML, Edwards, DP, Faccenda, E, Farndale, R, Fong, TM, Forrest, D, Fowler, CJ, Fuller, P, Gainetdinov, RR, Gershengorn, MA, Goldin, A, Goldstein, SAN, Grimm, SL, Grissmer, S, Gundlach, AL, Hagenbuch, B, Hammond, JR, Hancox, JC, Hartig, S, Hauger, RL, Hay, DL, Hebert, T, Hollenberg, AN, Holliday, ND, Hoyer, D, Ijzerman, AP, Inui, KI, Ishii, S, Jacobson, KA, Jan, LY, Jarvis, GE, Jensen, R, Jetten, A, Jockers, R, Kaczmarek, LK, Kanai, Y, Kang, HS, Karnik, S, Kelly, E, Kerr, ID, Korach, KS, Lange, CA, Larhammar, D, Leeb-Lundberg, F, Leurs, R, Lolait, SJ, Macewan, D, Maguire, JJ, Marrion, N, May, JM, Mazella, J, McArdle, CA, McDonnell, DP, Michel, MC, Miller, LJ, Mitolo, V, Monie, T, Monk, PN, Mouillac, B, Murphy, PM, Nahon, J-L, Nerbonne, J, Nichols, CG, Norel, X, Oakley, R, Offermanns, S, Palmer, LG, Panaro, MA, Pawson, AJ, Perez-Reyes, E, Pertwee, RG, Peters, JA, Pike, JW, Pin, JP, Pintor, S, Plant, LD, Poyner, DR, Prossnitz, ER, Pyne, S, Ren, D, Richer, JK, Rondard, P, Ross, RA, Sackin, H, Safi, R, Sanguinetti, MC, Sartorius, CA, Segaloff, DL, Sharman, JL, Sladek, FM, Southan, C, Stewart, G, Stoddart, LA, Striessnig, J, Summers, RJ, Takeda, Y, Tetel, M, Toll, L, Trimmer, JS, Tsai, M-J, Tsai, SY, Tucker, S, Usdin, TB, Vilargada, J-P, Vore, M, Ward, DT, Waxman, SG, Webb, P, Wei, AD, Weigel, N, Willars, GB, Winrow, C, Wong, SS, Wulff, H, Ye, RD, Young, M, Zajac, J-M   +150 more
core   +4 more sources

High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library.

Environmental Science and Technology, 2018
Thyroid uptake of iodide via the sodium-iodide symporter (NIS) is the first step in the biosynthesis of thyroid hormones that are critical for health and development in humans and wildlife.
Jun Wang, D. Hallinger, A. Murr, A. Buckalew, S. Simmons, S. Laws, T. Stoker   +6 more
semanticscholar   +1 more source

Reclamation of filtered bicarbonate [PDF]

, 1990
The kidney participates in the maintenance of acid-base homeostasis by 1) reabsorption of the filtered load of bicarbonate and 2) excretion of fixed acids through the titration of urinary buffers and the excretion of ammonium.
Dubose, Thomas D.
core   +1 more source