Pathophysiology, Clinical, and Therapeutic Aspects of Narcolepsy [PDF]
, 2014 Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, cataplexy, hypnagogic hallucination, and sleep paralysis. The exact cause remains unknown, but there is significant evidence that hypocretin deficiency plays an ...
Mustafa Gulec +3 more
core +1 more source
Alcohol-responsive Action Myoclonus of the Leg in Prostate Cancer: A Novel Paraneoplastic Syndrome?
Tremor and Other Hyperkinetic Movements, 2015 Background: Paraneoplastic movement disorders in prostate cancer are rare, and to our knowledge paraneoplastic myoclonus has not previously been reported.
Pichet Termsarasab, Steven J. Frucht
doaj +1 more source
Dreaming of Better Treatments: Advances in Drug Development for Sleep Medicine and Chronotherapy
Journal of Sleep Research, Volume 34, Issue 5, October 2025.ABSTRACT Throughout history, the development of new sleep medicines has been driven by progress in our understanding of the mechanisms underlying sleep. Ancient civilisations used their understanding of the sedative nature of natural herbs and compounds to induce sleep.
Brooke A. Prakash +5 more
wiley +1 more source
Progressive Supranuclear Palsy and Corticobasal Degeneration: Pathophysiology and Treatment Options [PDF]
, 2016 There are currently no disease-modifying treatments for progressive supranuclear palsy (PSP) or corticobasal degeneration (CBD), and no approved pharmacological or therapeutic treatments that are effective in controlling their symptoms.
Andrew J. Lees +3 more
core +1 more source
Association between objectively measured physical activity and opioid, hypnotic, or anticholinergic medication use in older people – data from the Physical Activity Cohort Scotland study [PDF]
, 2018 Background: Centrally acting medications cause cognitive slowing and incoordination, which could reduce older people’s physical activity levels. This association has not been studied previously.Objectives: To examine the association between opioid ...
A Moschny +36 more
core +2 more sources
Narcolepsy: a machine learning bibliometric analysis (1996–2024)
Frontiers in NeurologyBackgroundNarcolepsy is a rare neurological cause of chronic sleepiness. This study aimed to better understand global narcolepsy through bibliometric analysis.MethodsArticles and reviews on narcolepsy were sourced from the Web of Science Core Collection.
Minheng Zhang +3 more
doaj +1 more source
Therapeutic and toxic blood concentrations of nearly 1,000 drugs and other xenobiotics [PDF]
, 2012 Introduction: In order to assess the significance of drug levels measured in intensive care medicine, clinical and forensic toxicology, as well as for therapeutic drug monitoring, it is essential that a comprehensive collection of data is readily ...
Andresen, Hilke +3 more
core +1 more source
Pharmacokinetics and Excretion of Gamma-Hydroxybutyrate (GHB) in Healthy Subjects [PDF]
, 2017 In Europe and the United States, the recreational use of gammahydroxy butyric acid (GHB) at dance clubs and "rave” parties has increased substantially. In addition, GHB is used to assist in the commission of sexual assaults.
Brenneisen, Rudolf +6 more
core
Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study [PDF]
, 2011 Background The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood. Methods Sleep physiology, somatic and mood ...
Harvey Moldofsky, John Patcai
core +3 more sources
Diagnosis and management of central hypersomnias
Therapeutic Advances in Neurological Disorders, 2012 Central hypersomnias are diseases manifested in excessive daytime sleepiness (EDS) not caused by disturbed nocturnal sleep or misaligned circadian rhythms.
Karel Sonka, Marek Susta
doaj +1 more source