Results 161 to 170 of about 1,224,792 (212)

0855 Successful Transition from Twice-Nightly Oxybates to Once-Nightly Sodium Oxybate: A Post Hoc Analysis from RESTORE

Sleep
Extended-release, once-nightly sodium oxybate (ON-SXB; LUMRYZ™) eliminates the middle-of-the-night dosing required with immediate-release, twice-nightly oxybates (TN-OXBs).
Adrian Santamaria, John R. Harsh, Bruce C. Corser, J. Hudson, S. Ibrahim, Paula Schweitzer, B. Abaluck, J. Gudeman   +7 more
semanticscholar   +1 more source

Sodium-oxybate

Reactions Weekly, 2019
  +7 more sources

0836 Consistent Efficacy of Once-Nightly Sodium Oxybate on Disrupted Nighttime Sleep in People with Narcolepsy

Sleep
Once-nightly sodium oxybate (ON-SXB; LUMRYZ™) demonstrated efficacy in treating narcolepsy symptoms, including disrupted nighttime sleep (DNS), in the phase 3 REST-ON trial (NCT02720744).
Y. Dauvilliers, M.J. Thorpy, Thomas Roth, Clete A Kushida, A. Morse, John R. Harsh, Luis Ortiz, J. Gudeman   +7 more
semanticscholar   +1 more source

0851 Effectiveness and Safety of Low-Sodium Oxybate in Idiopathic Hypersomnia Participants: Results from the DUET Study

Sleep
Introduction: Jazz DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) is a phase 4, prospective, multicenter, single-arm, multiple-cohort, open-label study (NCT05875974) evaluating the effectiveness of low-sodium ...
D. Plante, A. Cairns, Logan D Schneider, Deborah A. Nichols, T. Steininger, D. Fuller, M. Kirby, Sarah Akerman, Jessica K Alexander, M. Whalen, Chad Ruoff   +10 more
semanticscholar   +1 more source

0857 REFRESH: Prospective, Observational Study Design of Once-Nightly Sodium Oxybate for Narcolepsy in Clinical Practice

Sleep
Once-nightly sodium oxybate (ON-SXB; LUMRYZ™) is approved to treat excessive daytime sleepiness and cataplexy in adult and pediatric patients ≥7 years of age with narcolepsy.
S. Meskill, G. Meskill, Laura Herpel, Adrian Santamaria, J.D. McConnell, O. Mamedov, R. Porpiglio, E. Friedman, B. Abaluck, J. Gudeman   +9 more
semanticscholar   +1 more source

0852 Subjective Sleep Quality with Low-Sodium Oxybate Treatment in Idiopathic Hypersomnia: Results from the DUET Study

Sleep
Jazz DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) is a phase 4, prospective, multicenter, single-arm, multiple-cohort, open-label study (NCT05875974) evaluating the effectiveness of low-sodium oxybate (LXB ...
Richard Bogan, D. Plante, A. Cairns, Deborah A. Nichols, T. Steininger, D. Fuller, Sarah Akerman, M. Whalen, N. Foldvary-Schaefer   +8 more
semanticscholar   +1 more source

0853 Sleep Architecture with Low-Sodium Oxybate Treatment in Idiopathic Hypersomnia: Results from the DUET Study

Sleep
Jazz DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) is a phase 4, prospective, multicenter, single-arm, multiple-cohort, open-label study (NCT05875974) evaluating the effectiveness of low-sodium oxybate (LXB ...
A. Cairns, Richard Bogan, N. Foldvary-Schaefer, Deborah A. Nichols, T. Steininger, D. Fuller, Sarah Akerman, Jessica K Alexander, D. Plante   +8 more
semanticscholar   +1 more source

0862 Sleep Architecture with Low-Sodium Oxybate Treatment in Narcolepsy: Results from the DUET Study

Sleep
Jazz DUET (Develop hypersomnia Understanding by Evaluating low-sodium oxybate Treatment) is a phase 4, prospective, multicenter, single-arm, multiple-cohort, open-label study (NCT05875974) evaluating effectiveness of low-sodium oxybate (LXB, Xywav®)
Chad Ruoff, Logan D Schneider, R. Sangal, Deborah A. Nichols, T. Steininger, D. Fuller, M. Kirby, Jessica K Alexander, Emmanuel Mignot   +8 more
semanticscholar   +1 more source

Effects of low-sodium oxybate on diary-based sleep time in a clinical study in adults with idiopathic hypersomnia.

Sleep Medicine
OBJECTIVES Prolonged nighttime sleep is a prominent symptom in many patients with idiopathic hypersomnia. The only US Food and Drug Administration-approved treatment for idiopathic hypersomnia is low-sodium oxybate (LXB; Xywav®), for which efficacy and ...
A. Morse, Y. Dauvilliers, Logan D. Schneider, Douglas S Fuller, T. Steininger, Jed Black, M.J. Thorpy   +6 more
semanticscholar   +1 more source

Abstract FR498: Impact of Switching From High- to Low-Sodium Oxybate on Ambulatory and Office Blood Pressure in Subgroups of People With Narcolepsy From the XYLO Study

HYPERTENSION
Introduction: Excess sodium intake is strongly linked with hypertension and cardiovascular disease (CVD); people with narcolepsy (PwN) have increased CV risk.
Virend Somers, Richard Kovacs, Jessica K. Alexander, C. Baranak, Deborah A. Nichols, Jing Dai, Marisa Whalen, A. Ajayi, Barbara Hutchinson, Y. Dauvilliers, William B. White   +10 more
semanticscholar   +1 more source