Results 171 to 180 of about 11,107 (217)
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Toxicological studies with sodium cyclamate and saccharin
Food and Cosmetics Toxicology, 1968Abstract The effects of acute, subacute and chronic administration of sodium cyclamate, sodium saccharin or combinations of cyclamate and saccharin have been studied in mice, rats and dogs. The acute toxicity of the materials was shown to vary with the strain of animal and the fat content of the diet.
J.D. Taylor +3 more
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Spectrophotometric determination of sodium cyclamate and saccharin sodium with Astrazone Pink FG
The Analyst, 1984[No abstract available]
Özol T. +3 more
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Thermal investigation on polymorphism in sodium saccharine
Journal of Thermal Analysis and Calorimetry, 2014The thermal behavior of sodium saccharin polymorphic forms was investigated using thermogravimetry and differential scanning calorimetry, while structural changes during the dehydration processes were monitored by X-ray powder diffraction. In solid state, sodium saccharine may exhibit three forms: anhydrate, 2/3 hydrate (triclinic), and 15/8 hydrate ...
Deyber Arley Vargas Medina +2 more
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Study of sodium saccharin co-carcinogenicity in the rat
Food and Chemical Toxicology, 1994A co-carcinogenicity experiment was conducted with female Sprague-Dawley rats in which the effects of short-term sodium saccharin dosing and initiation with a direct-acting carcinogen were examined in the urinary bladder. All initiated animals were administered 0.5 mg N-methyl-N-nitrosourea (MNU) by instillation into the bladder at 8 wk of age.
R W, West +4 more
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Sodium Cyclamate, Saccharin and Food Efficiency
Nature, 1969FOLLOWING experiments with 0.43 per cent sodium cyclamate in rat's food1 in which rats consuming cyclamate had a better food efficiency than the controls, I performed two further experiments using two basic rations; saccharin was introduced, and both sweetening agents were given in varying amounts to weanling Wistar strain albino rats of both sexes ...
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The inhibition of urease and proteases by sodium saccharin
Cancer Letters, 1982Sodium saccharin, at concentrations similar to those in the urine of rats fed 1-5% sodium saccharin in their diet, markedly inhibited urease, and 3 proteases in vitro and sodium ion did not appear to play a role in enzyme inhibition. These observations suggest that enzyme inhibition of any of a large number of enzymes may play a role in the ...
E, Lok, F, Iverson, D B, Clayson
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Antimutagenesis in Yeast by Sodium Chloride, Potassium Chloride, and Sodium Saccharin
1990Aqueous salt solutions containing NaCl, KCl, MgCl2, Na2SO4, CaCl2, NH4Cl, or sodium saccharin are mutagenic in yeast when logarithmic growth of cells is interrupted by exposure to a 0.5-2.0 M salt solution. Stationary-phase cells are not mutated by this treatment.
K R, Parker, R C, von Borstel
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Alterations in the rat kidney associated with sodium saccharin feeding
Toxicology Letters, 1982Sodium saccharin has previously been demonstrated to induce hyperplasia and tumors of the urothelium of the rat urinary bladder. It was fed as 5% of the diet to male F344 rats for 2 years. In the present experiment, mild simple hyperplasia of the urinary bladder epithelium was again frequently observed, and a marked nodular and papillary hyperplasia of
G, Murasaki, R E, Greenfield, S M, Cohen
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Subacute toxicity studies with sodium saccharin and two hydrolytic derivatives
Toxicology, 1976The subacute toxicity of sodium saccharin and 2 hydrolytic derivatives, o-sulfamoylbenzoic acid (Compound I) and ammonium o-carboxybenzene sulfonate (Compound II) was evaluated by feeding each of the compounds alone at a dietary level of 20 000 ppm to both beagle dogs and albino rats. Additionally, groups of dogs and rats were fed combinations of the 3
G L, Kennedy +2 more
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Production of Urinary Bladder Carcinomas in Mice by Sodium Saccharin
Science, 1970Pellets weighing 20 to 24 milligrams and containing 20 percent sodium saccharin suspended in cholesterol were surgically implanted into the urinary bladder lumens of female Swiss mice (60 to 90 days old) under ether anesthesia. Incidences of mouse bladder carcinomas in animals exposed to these pellets were 47 and 52 percent as compared with incidences ...
G T, Bryan, E, Ertürk, O, Yoshida
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