Results 171 to 180 of about 572,493 (204)
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Toxicology in Vitro, 1989
The in vitro effects of saccharin were evaluated in a transformed rat-bladder epithelial cell line. AY-27 cells were seeded in a 35-mm tissue culture well and incubated for 24 hr with saccharin or other test compounds dissolved in the media. The cytotoxic effects of saccharin were dependent on the salt form tested.
E M, Garland +3 more
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The in vitro effects of saccharin were evaluated in a transformed rat-bladder epithelial cell line. AY-27 cells were seeded in a 35-mm tissue culture well and incubated for 24 hr with saccharin or other test compounds dissolved in the media. The cytotoxic effects of saccharin were dependent on the salt form tested.
E M, Garland +3 more
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A review and biological risk assessement of sodium saccharin
Regulatory Toxicology and Pharmacology, 1992Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration, and volume are elevated and proliferative changes are present in the urothelium. Extensive epidemiological studies have shown that saccharin does not increase the risk of bladder cancer in humans ...
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Saccharin sodium as a potential sweetener for antidotal charcoal
American Journal of Health-System Pharmacy, 1977This study explored if saccharin sodium, as a sweetener in activated charcoal formulations, would be sufficiently available to provide sweetness while not severely reducing charcoal's adsorption capacity. In vitro tests showed that charcoal takes up 40wt% of saccharin at a 1 g/liter concentration of saccharin in the residual fluid; 29.3wt% at 0.1 g ...
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Effect of sodium saccharin on the neonatal rat bladder.
Scanning microscopy, 1996In a two-generation bioassay, high doses of dietary sodium saccharin (NaSac) produce bladder carcinoma in rats, whereas acid saccharin (HSac) does not effect the urothelium. NaSac and HSac administered as 5% of the diet to F0 Sprague-Dawley (SD) and F344 rats, continued through to the weaned male rats for ten additional weeks.
Cohen, Samuel M. +5 more
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Food and Chemical Toxicology, 1985
The literature indicates that sodium saccharin is non-reactive to DNA and inactive as a gene mutagen in vitro. At elevated dose levels it is capable of producing structural disturbances in eukaryotic chromosomes in vitro, and it shows intermittent activity as a very weak germ-cell and somatic-cell mutagen in vivo.
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The literature indicates that sodium saccharin is non-reactive to DNA and inactive as a gene mutagen in vitro. At elevated dose levels it is capable of producing structural disturbances in eukaryotic chromosomes in vitro, and it shows intermittent activity as a very weak germ-cell and somatic-cell mutagen in vivo.
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Journal of Biomolecular Structure and Dynamics, 2019
In the past few decades, extensive discussions have been on the impact of artificial sweeteners on the risk of cancer. The present study aimed to evaluate the interaction of saccharin (SA) and sodium saccharin (SSA) with the promoter of the human p53 gene.
Mahboubeh, Mansourian +4 more
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In the past few decades, extensive discussions have been on the impact of artificial sweeteners on the risk of cancer. The present study aimed to evaluate the interaction of saccharin (SA) and sodium saccharin (SSA) with the promoter of the human p53 gene.
Mahboubeh, Mansourian +4 more
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Effect of short-term administration of sodium saccharin on rhesus monkeys
Food and Chemical Toxicology, 1984Sodium saccharin (NaS) was incorporated into biscuits or the drinking-water and fed to rhesus monkeys at progressively increasing doses in order to determine the maximum dose that the monkeys would voluntarily consume and/or tolerate. Very little rejection of NaS-treated biscuits or drinking-water was observed. However, severe diarrhoea which precluded
G.P. Schoenig +2 more
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Assay of saccharin and sodium saccharin in animal feed
Journal of Chromatography A, 1982H S, Tan, P W, Pan
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Journal of Chromatography A, 1984
A reversed-phase high-performance liquid chromatographic procedure for the determination of o-toluenesulfonamide and p-toluenesulfonamide in saccharin and saccharin sodium is described. In a second step, polar byproducts of the synthesis and related polar substances are determined in a lower sensitivity range.
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A reversed-phase high-performance liquid chromatographic procedure for the determination of o-toluenesulfonamide and p-toluenesulfonamide in saccharin and saccharin sodium is described. In a second step, polar byproducts of the synthesis and related polar substances are determined in a lower sensitivity range.
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