Results 81 to 90 of about 14,659,030 (367)

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Recent Advances in Visualizing Multivariate Linear Models

open access: yesRevista Colombiana de Estadística, 2014
This paper reviews our work in the development of visualization methods (implemented in \R) for understanding and interpreting the effects of predictors in multivariate linear models (MLMs) of the form Y = X B + U, and some of their recent extensions. We
MICHAEL FRIENDLY, MATTHEW SIGAL
doaj   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

open access: yesFEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász   +6 more
wiley   +1 more source

Software for the simulation of gases separation instalations with zeolite membranes

open access: yesRevista Cubana de Ciencias Informáticas, 2013
The simulation of gases separation processes is a very important field of the scientific work; it affects directly the chemical technologies related to petroleum refining, petrochemical, fine chemistry, gaseous fuels (methane, synthetic gas and ...
Yoenia M. Martínez Díaz   +3 more
doaj  

Case Report: Fatigue and Bleeding in a Polymedicated Patient Using Several Herbal Supplementations, Detected with g-Nomic® Software

open access: yesPharmacogenomics and Personalized Medicine, 2021
Abel Saldarreaga Marin,1 Marc Cendros,2 Carlos J Ciudad,3 Ana Sabater2 1Bahía de Cádiz-La Janda Health District, Mobile Emergency Unit of the Andalusian Health Care, Service of Cádiz, Cádiz, Spain; 2Eugenomic, Barcelona, Spain; 3Biochemistry and ...
Saldarreaga Marin A   +3 more
doaj  

Software survey: VOSviewer, a computer program for bibliometric mapping

open access: yesScientometrics, 2009
We present VOSviewer, a freely available computer program that we have developed for constructing and viewing bibliometric maps. Unlike most computer programs that are used for bibliometric mapping, VOSviewer pays special attention to the graphical ...
Nees Jan van Eck, L. Waltman
semanticscholar   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

open access: yesFEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi   +5 more
wiley   +1 more source

BEWARE, PERSON-YEARS! EXPERIENCE OF SIMPSON PARADOX OBSERVATION IN EPIDEMIOLOGICAL RISK EXAMINATIONS

open access: yesAnaliz Riska Zdorovʹû, 2017
It is shown, on the examples of concrete publications, that "person-years" category application in multi-factor health risks analysis can lead to false conclusions in the process of observation data grouping due to Simpson paradox influence when ...
V.F. Obesnyuk
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

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