Results 81 to 90 of about 12,191,945 (322)

Sustainable Software Ecosystems: Software Engineers, Domain Scientists, and Engineers Collaborating for Science

, 2014
The development of scientific software is often a partnership between domain scientists and scientific software engineers. It is especially important to embrace these collaborations when developing advanced scientific software, where sustainability ...
Hanwell, Marcus D., O'Bara, Bob, O'Leary, Patrick   +2 more
core   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

RSS (http://www.iaees.org/publications/journals/ces/rss.xml)

Computational Ecology and Software
Computational Ecology and Software ISSN 2220-721X
Computational Ecology and Software (ISSN 2220-721X)
doaj  

Parallel programming software package GraphPlus Templet

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011
The parallel programming automation software package named Graphplus templet is considered. Its design purposes, architecture, efficiency of applying for numerical modeling problems solutions, features against similar approaches are discussed.
Sergey V Vostokin, Andrey R Khayrutdinov, Vladimir G Litvinov   +2 more
doaj  

On the naturalness of software

Communications of the ACM, 2012
Natural languages like English are rich, complex, and powerful. The highly creative and graceful use of languages like English and Tamil, by masters like Shakespeare and Avvaiyar, can certainly delight and inspire. But in practice, given cognitive constraints and the exigencies of daily life, most human utterances are far simpler and much more ...
Hindle, Abram, Barr, E.T., Su, Z., Devanbu, P.T., Gabel, M.   +4 more
openaire   +6 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Recent Advances in Visualizing Multivariate Linear Models

Revista Colombiana de Estadística, 2014
This paper reviews our work in the development of visualization methods (implemented in \R) for understanding and interpreting the effects of predictors in multivariate linear models (MLMs) of the form Y = X B + U, and some of their recent extensions. We
MICHAEL FRIENDLY, MATTHEW SIGAL
doaj   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Case Report: Fatigue and Bleeding in a Polymedicated Patient Using Several Herbal Supplementations, Detected with g-Nomic® Software

Pharmacogenomics and Personalized Medicine, 2021
Abel Saldarreaga Marin,1 Marc Cendros,2 Carlos J Ciudad,3 Ana Sabater2 1Bahía de Cádiz-La Janda Health District, Mobile Emergency Unit of the Andalusian Health Care, Service of Cádiz, Cádiz, Spain; 2Eugenomic, Barcelona, Spain; 3Biochemistry and ...
Saldarreaga Marin A, Cendros M, Ciudad CJ, Sabater A   +3 more
doaj